神经节苷脂GM4对实验性变应性脑脊髓炎的预防作用
Prevention of experimental allergic encephalomyelitis by ganglioside GM4.
作者信息
Mullin B R, Patrick D H, Poore C M, Smith M T
出版信息
Brain Res. 1984 Mar 26;296(1):174-6. doi: 10.1016/0006-8993(84)90527-4.
Guinea pigs inoculated with a mixture of myelin basic protein and the myelin-specific ganglioside, sialosylgalactosylceramide (GM4), do not develop the signs or neuropathology of experimental allergic encephalomyelitis. The results indicate that GM4 cloaks the basic protein molecule so that it is no longer immunopathogenic in these animals. The interaction of basic protein with GM4, previously shown in vitro, appears to be relevant to the pathogenesis of experimental allergic encephalomyelitis in guinea pigs.
用髓鞘碱性蛋白和髓鞘特异性神经节苷脂唾液酸半乳糖基神经酰胺（GM4）的混合物接种的豚鼠，不会出现实验性变应性脑脊髓炎的体征或神经病理学改变。结果表明，GM4包裹了碱性蛋白分子，使其在这些动物中不再具有免疫致病性。先前在体外显示的碱性蛋白与GM4的相互作用，似乎与豚鼠实验性变应性脑脊髓炎的发病机制有关。
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