不同梅毒亚种中的两个16S - 23S核糖体DNA基因间隔区含有tRNA基因。
Two 16S-23S ribosomal DNA intergenic regions in different Treponema pallidum subspecies contain tRNA genes.
作者信息
Centurion-Lara A, Castro C, van Voorhis W C, Lukehart S A
机构信息
Department of Medicine, University of Washington, Harborview Medical Center, Seattle 98104, USA.
出版信息
FEMS Microbiol Lett. 1996 Oct 1;143(2-3):235-40. doi: 10.1111/j.1574-6968.1996.tb08486.x.
The 16S-23S intergenic spacers of Treponema pallidum subspecies pallidum, Nichols strain, and Treponema pallidum subspecies pertenue, Gauthier strain, have been cloned, characterized and sequenced. Isoleucine and alanine tRNA genes have been identified within the 16S-23S intergenic regions on separate alleles of 293 and 303 bases, respectively. The two alleles are present in both T.p.pallidum and T.p. pertenue, and show no sequence differences between the bacterial subspecies. The ile-tRNA and ala-tRNA genes show 65% and 84% sequence identity, respectively, with the homologous genes of the related spirochete, Borrelia burgdorferi.
梅毒亚种苍白亚种（Nichols菌株）和雅司螺旋体亚种（Gauthier菌株）的16S - 23S基因间隔区已被克隆、鉴定和测序。在16S - 23S基因间隔区内分别在293个碱基和303个碱基的不同等位基因上鉴定出了异亮氨酸和丙氨酸tRNA基因。这两个等位基因存在于梅毒亚种苍白亚种和雅司螺旋体亚种中，并且在这两个细菌亚种之间没有序列差异。异亮氨酸tRNA基因和丙氨酸tRNA基因与相关螺旋体伯氏疏螺旋体的同源基因的序列同一性分别为65%和84%。
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