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乳腺癌和肠癌女性患者的死因

Causes of death among female patients with cancer of the breast and intestines.

作者信息

Hakulinen T, Teppo L

出版信息

Ann Clin Res. 1977 Feb;9(1):15-24.

PMID:883752
Abstract

The cause-specific mortality of women with cancer of the breast or of the intestines (= small intestine and colon) diagnosed in 1953-70 in Finland was analyzed with respect to the extent of the disease, the age of the patient at the time of diagnosis, and the follow-up time. The total mortality in breast-cancer patients was higher than had been expected during the entire follow-up period (maximum of 18 years), whereas in patients with intestinal cancer no more than slight excess mortality existed after 5 years of follow-up. The mortality from cardiovascular diseases was less than had been expected among patients with intestinal cancer. Patients with non-localized cancer of the breast had a risk of dying from accidents and other violent causes of death during the first 5 years of follow-up which was slightly higher than expected. From information compiled from various sources, the Finnish Cancer Registry records not only the official cause of death mentioned on the death certificate, but also a "corrected" cause of death. With this correction, the mortality from forms of malignancy other than the primary cancer was lower than had been expected during the first 5 years of follow-up, and subsequently reached the level expected. In regard to specific sites, mortality lower than that expected was observed for cancer of the stomach (both breast- and intestinal-cancer patients), and cancer of the cervix uteri (breast-cancer patients). In patients with localized breast cancer, the mortality from leukaemia was higher than that expected after 5 years of follow-up. No mutual excess risk was demonstrable with breast and intestinal cancers.

摘要

对1953年至1970年期间在芬兰诊断出患有乳腺癌或肠癌(=小肠和结肠癌)的女性,按疾病程度、诊断时患者年龄及随访时间分析了死因特异性死亡率。在整个随访期(最长18年)内,乳腺癌患者的总死亡率高于预期,而肠癌患者在随访5年后仅存在轻微的超额死亡率。肠癌患者中心血管疾病导致的死亡率低于预期。非局限性乳腺癌患者在随访的前5年因意外及其他暴力死因死亡的风险略高于预期。根据从各种来源收集的信息,芬兰癌症登记处不仅记录死亡证明上提到的官方死因,还记录“校正后”的死因。经此校正,除原发性癌症外的其他恶性肿瘤形式导致的死亡率在随访的前5年低于预期,随后达到预期水平。就特定部位而言,胃癌(乳腺癌和肠癌患者)及子宫颈癌(乳腺癌患者)的死亡率低于预期。在局限性乳腺癌患者中,随访5年后白血病导致的死亡率高于预期。乳腺癌和肠癌之间未显示出相互超额风险。

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