诊断后20年乳腺癌导致的超额死亡率，此时预期寿命正常。
Excess mortality from breast cancer 20 years after diagnosis when life expectancy is normal.
作者信息
Louwman W J, Klokman W J, Coebergh J W
机构信息
Eindhoven Cancer Registry, Comprehensive Cancer Centre South (IKZ), PO Box 231, Eindhoven, 5600 AE, The Netherlands.
出版信息
Br J Cancer. 2001 Mar 2;84(5):700-3. doi: 10.1054/bjoc.2000.1616.
In a population-based study, causes of death were traced of 418 deceased breast cancer patients diagnosed in 1960-1979 who survived at least 10 years after diagnosis. The pattern of causes of death in these patients was compared with the general female population using standardized mortality ratios (SMRs). Of 418 patients surviving at least 10 years, 196 (47%) died from breast cancer and 50 (12%) died from another cancer. The SMR for breast cancer was 15.8 (95% CI: 13.1-18.8) 10-14 years after diagnosis; it was still 4.7 (95% CI: 2.6-7.8) after 20 years. Overall mortality was higher than expected 10-14 years after diagnosis (SMR: 1.3; 95% CI: 1.1-1.5), but lower after more than 20 years (SMR: 0.6; 95% CI: 0.4-0.7). Despite a normal (or even improved) life expectancy for breast cancer patients 20 years after diagnosis the risk of dying from this disease remained elevated.
在一项基于人群的研究中，追踪了1960年至1979年确诊的418例已故乳腺癌患者的死因，这些患者在确诊后至少存活了10年。使用标准化死亡率（SMR）将这些患者的死因模式与一般女性人群进行了比较。在至少存活10年的418例患者中，196例（47%）死于乳腺癌，50例（12%）死于另一种癌症。确诊后10至14年，乳腺癌的SMR为15.8（95%置信区间：13.1 - 18.8）；20年后仍为4.7（95%置信区间：2.6 - 7.8）。确诊后10至14年总体死亡率高于预期（SMR：1.3；95%置信区间：1.1 - 1.5），但20多年后则较低（SMR：0.6；95%置信区间：0.4 - 0.7）。尽管确诊20年后乳腺癌患者的预期寿命正常（甚至有所改善），但死于该病的风险仍然很高。
Zotero 插件