The dilemma of the prolonged QT interval in early drug studies.

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作者信息

Thomas M, Maconochie J G, Fletcher E

机构信息

Clinical Pharmacology and Dynamics Department, Glaxo Research and Development Ltd, Ware, Hertfordshire.

出版信息

Br J Clin Pharmacol. 1996 Feb;41(2):77-81. doi: 10.1111/j.1365-2125.1996.tb00163.x.

DOI:10.1111/j.1365-2125.1996.tb00163.x

PMID:8838432

Abstract

摘要

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The dilemma of the prolonged QT interval in early drug studies.

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引用本文的文献

Lenalidomide at therapeutic and supratherapeutic doses does not prolong QTc intervals in the thorough QTc study conducted in healthy men.

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相似文献

The dilemma of the prolonged QT interval in early drug studies.

Br J Clin Pharmacol. 1996 Feb;41(2):77-81. doi: 10.1111/j.1365-2125.1996.tb00163.x.

[Acquired long QT syndrome].

Rev Med Suisse. 2013 Aug 28;9(395):1538-42.

QT interval and drug therapy.

Drug Ther Bull. 2016 Mar;54(3):33-6. doi: 10.1136/dtb.2016.3.0390.

A wearable remote monitoring system for the identification of subjects with a prolonged QT interval or at risk for drug-induced long QT syndrome.

Int J Cardiol. 2018 Sep 1;266:89-94. doi: 10.1016/j.ijcard.2018.03.097.

[Prolongation of QT interval and evaluation of safety of drugs].

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2013 Aug;30(4):905-8.

The impact of drug-related QT prolongation on FDA regulatory decisions.

Int J Cardiol. 2013 Oct 12;168(5):4975-6. doi: 10.1016/j.ijcard.2013.07.136. Epub 2013 Aug 3.

[QT drugs--what is the clinical significance?].

Ugeskr Laeger. 2013 Jun 3;175(23):1663.

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Eur J Clin Pharmacol. 2018 Feb;74(2):183-191. doi: 10.1007/s00228-017-2381-5. Epub 2017 Nov 22.

[Risk of sudden cardiac death induced by QT drugs].

Ugeskr Laeger. 2013 Jun 3;175(23):1666.

Drug-induced QT Interval Prolongation in the Intensive Care Unit.

Curr Clin Pharmacol. 2017;12(4):210-222. doi: 10.2174/1574884713666180223123947.

引用本文的文献

Lenalidomide at therapeutic and supratherapeutic doses does not prolong QTc intervals in the thorough QTc study conducted in healthy men.

Basic Clin Pharmacol Toxicol. 2013 Sep;113(3):179-86. doi: 10.1111/bcpt.12081. Epub 2013 Jun 20.

Designing and interpreting the results of first-time-to-man studies.

Dialogues Clin Neurosci. 2000 Sep;2(3):203-12. doi: 10.31887/DCNS.2000.2.3/apatat.

Pharmacokinetic-pharmacodynamic modeling in the data analysis and interpretation of drug-induced QT/QTc prolongation.

AAPS J. 2005 Oct 24;7(3):E609-24. doi: 10.1208/aapsj070363.

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Curr Control Trials Cardiovasc Med. 2005 Feb 3;6(1):1. doi: 10.1186/1468-6708-6-1.

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Drug Saf. 2003;26(6):421-38. doi: 10.2165/00002018-200326060-00004.

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