Strieker M J, Morris J G, Feldman B F, Rogers Q R
Department of Molecular Biology, School of Veterinary Medicine, University of California, Davis 95616, USA.
J Small Anim Pract. 1996 Jul;37(7):322-6. doi: 10.1111/j.1748-5827.1996.tb02400.x.
Clinical signs of vitamin K deficiency have been observed in cats offered two commercial canned diets high in salmon or tuna. Some of the queens and kittens offered these diets had died while survivors had increased coagulation times. Necropsies revealed hepatic and, or, gastrointestinal haemorrhages. Coagulation times of survivors returned to normal after vitamin K therapy. The purpose of this study was to induce a vitamin K deficiency in kittens and determine the dietary requirement. Kittens were offered vitamin K-deficient purified diets containing antibiotics and, or, substances inherent in canned fish diets that may have contributed to the deficiency. Clinical signs of vitamin K deficiency were not observed, even though one purified diet contained only 4 micrograms K1/kg diet compared with 60 micrograms in the commercial tuna diet. Therefore, a minimum vitamin K requirement could not be determined using purified diets; nevertheless, canned commercial diets formulated primarily with fish should contain more than 60 micrograms K1/kg diet.
给猫喂食两种富含三文鱼或金枪鱼的商业罐装猫粮后，观察到了维生素K缺乏的临床症状。一些食用这些猫粮的母猫和小猫死亡，而存活下来的猫凝血时间延长。尸检发现有肝脏和/或胃肠道出血。维生素K治疗后，存活猫的凝血时间恢复正常。本研究的目的是诱发小猫维生素K缺乏并确定其饮食需求量。给小猫喂食缺乏维生素K的纯化日粮，其中含有抗生素和/或罐装鱼日粮中可能导致维生素K缺乏的固有物质。尽管有一种纯化日粮每千克日粮仅含4微克维生素K1，而商业金枪鱼日粮中为60微克，但并未观察到维生素K缺乏的临床症状。因此，使用纯化日粮无法确定维生素K的最低需求量；不过，主要由鱼类制成的商业罐装日粮每千克日粮应含有超过60微克的维生素K1。
