Alsulyman O M, Castro M A, Zuckerman E, McGehee W, Goodwin T M
Department of Obstetrics and Gynecology, University of Southern California School of Medicine, Los Angeles, USA.
Obstet Gynecol. 1996 Oct;88(4 Pt 2):644-6. doi: 10.1016/0029-7844(96)00098-1.
Usually, preeclampsia is a disease of the second half of pregnancy (i.e., beyond 20 weeks' gestation). Early-onset preeclampsia has been reported in association with the antiphospholipid syndrome, however, the cases reported have been at 25-30 weeks' gestation.
Three pregnant women presented with clinical and laboratory features of severe preeclampsia and the syndrome of hemolysis, elevated liver enzymes, and low platelets (HELLP) before 20 weeks' gestation. On evaluation, they were found to have antiphospholipid antibodies (anticardiolipin and/or lupus anticoagulant). Two of the patients had abdominal computed tomography scans that showed a low-density area along the hepatic periphery, compatible with hepatic infarction. Spontaneous resolution of all clinical and laboratory manifestations of preeclampsia and HELLP syndrome was observed after fetal death and pregnancy termination.
Preeclampsia and HELLP syndrome can present before 20 weeks' gestation in association with the antiphospholipid syndrome and may be associated with hepatic infarction.
通常，子痫前期是一种妊娠后半期（即妊娠20周后）的疾病。然而，早发型子痫前期已被报道与抗磷脂综合征有关，不过所报道的病例均在妊娠25 - 30周。
三名孕妇在妊娠20周前出现了重度子痫前期及溶血、肝酶升高和血小板减少综合征（HELLP）的临床和实验室特征。经评估，她们被发现存在抗磷脂抗体（抗心磷脂和/或狼疮抗凝物）。其中两名患者进行了腹部计算机断层扫描，显示肝周低密度区，符合肝梗死表现。胎儿死亡及终止妊娠后，子痫前期和HELLP综合征的所有临床和实验室表现均自发缓解。
子痫前期和HELLP综合征可在妊娠20周前与抗磷脂综合征相关出现，且可能与肝梗死有关。
