D'Amore P A, Shima D T
Laboratory for Surgical Research, Children's Hospital, Boston, MA 02115, USA.
Cancer Metastasis Rev. 1996 Jun;15(2):205-12. doi: 10.1007/BF00437473.
Continued tumor growth is dependent upon the growth of new blood vessels. This commentary reviews the mechanisms whereby tumors become vascularized and examines whether tumor angiogenesis is solely an example of a normal physiologic process or is part of the genetic program of the tumor. The likelihood that neovascularization of tumors combines both of these components, that is, utilizing tumor-specific elements as well as capacities common to all cells, is discussed.
肿瘤的持续生长依赖于新血管的生成。本评论综述了肿瘤血管化的机制，并探讨肿瘤血管生成是否仅仅是正常生理过程的一个例子，还是肿瘤基因程序的一部分。本文还讨论了肿瘤新生血管化结合这两个组成部分的可能性，即利用肿瘤特异性元件以及所有细胞共有的能力。
