Klein B E, Klein R, Moss S E, Cruickshanks K J
Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison 53705-2397, USA.
Diabetes Care. 1996 Aug;19(8):827-30. doi: 10.2337/diacare.19.8.827.
To evaluate the relative frequency of parental history of diabetes in a population-based study of younger- and older-onset groups of individuals with diabetes and a comparison group of individuals without diabetes.
Study participants were queried about a family history of diabetes. The frequencies of positive responses for parents and siblings were compared between younger- and older-onset groups.
At least one parent had diabetes in 18.6% of the families of younger-onset individuals and in 38.6% of the families of older-onset individuals. For those of younger-onset diabetes, 9.1% of fathers, 8.3% of mothers, and 1.3% of both parents had diabetes; the corresponding percentage for those of older-onset diabetes were 11.5, 23.5, and 3.6%, respectively. The difference between frequencies in mothers and fathers was significant (P < 0.0001) in the older-onset group. In the nondiabetic comparison group, for those of similar ages to the younger- and older-onset groups, the corresponding frequencies were 6.2 and 9.0% and 7.7 and 9.8% for fathers and mothers, respectively. The greater frequencies of diabetes in mothers of older-onset diabetic individuals were not accounted for by maternal age. In younger-onset individuals, the relative risk (RR) of diabetes in a sibling if the father had diabetes was 1.22 (95% CI, 0.72-2.05); if the mother had diabetes, the RR was 2.39 (95% CI, 1.64-3.48); and, if both parents had diabetes, the RR was 5.61 (95% CI, 3.37-9.34). In the older-onset individuals, the corresponding RR values were 1.69 (95% CI, 1.35-2.13) for fathers, 1.72 (95% CI, 1.44-2.06) for mothers, and 2.42 (95% CI, 1.81-3.25) for both parents.
These data confirm a familial influence on the frequency of diabetes. The excess of cases in mothers of older-onset diabetic individuals is compatible with both environmental and genetic influences.
在一项基于人群的研究中，评估糖尿病发病年龄较小和较大的个体组以及无糖尿病个体的对照组中糖尿病家族史的相对频率。
询问研究参与者糖尿病家族史。比较发病年龄较小和较大的个体组中父母及兄弟姐妹的阳性反应频率。
发病年龄较小的个体家庭中，18.6%的家庭至少有一位父母患有糖尿病；发病年龄较大的个体家庭中，这一比例为38.6%。对于发病年龄较小的糖尿病患者，9.1%的父亲、8.3%的母亲以及1.3%的父母双方患有糖尿病；发病年龄较大的糖尿病患者的相应比例分别为11.5%、23.5%和3.6%。在发病年龄较大的个体组中，母亲和父亲的患病频率差异具有统计学意义（P < 0.0001）。在无糖尿病对照组中，与发病年龄较小和较大个体组年龄相仿的人群中，父亲和母亲的相应频率分别为6.2%和9.0%以及7.7%和9.8%。发病年龄较大的糖尿病患者母亲中较高的糖尿病频率不能用母亲的年龄来解释。在发病年龄较小的个体中，如果父亲患有糖尿病，其兄弟姐妹患糖尿病的相对风险（RR）为1.22（95%CI，0.72 - 2.05）；如果母亲患有糖尿病，RR为2.39（95%CI，1.64 - 3.48）；如果父母双方都患有糖尿病，RR为5.61（95%CI，3.37 - 9.34）。在发病年龄较大的个体中，父亲、母亲以及父母双方的相应RR值分别为1.69（95%CI，1.35 - 2.13）、1.72（95%CI，1.44 - 2.06）和2.42（95%CI，1.81 - 3.25）。
这些数据证实了家族因素对糖尿病发病频率的影响。发病年龄较大的糖尿病患者母亲中病例数过多，这与环境和遗传因素的影响均相符。
