Duquesnoy R J, Filip D J, Aster R H
Blood. 1977 Sep;50(3):407-12.
Platelet transfusions from donors selectively mismatched for cross-reactive and certain non-cross-reactive HLA antigens were found to be more effective in HLA-A2 negative than in HLA-A2 positive, alloimmunized thrombocytopenic patients. The two groups of patients responded equally well to platelets matched for antigens of the HLA-A and B loci. Certain alloimmunized patients negative for HLA-A2 continued to respond satisfactorily to platelets selectively mismatched for non-cross-reactive HLA antigens as long as platelets containing HLA-A2 were avoided. The data indicate that platelet transfusion support can be provided within a broader range of donor-recipient HLA antigenic disparity to HLA-A2 negative alloimmunized patients than to those who are positive for this antigen.
对于交叉反应性和某些非交叉反应性HLA抗原选择性不匹配的供者的血小板输注，在HLA - A2阴性的同种免疫性血小板减少症患者中比在HLA - A2阳性患者中更有效。两组患者对HLA - A和B位点抗原匹配的血小板反应同样良好。只要避免使用含有HLA - A2的血小板，某些HLA - A2阴性的同种免疫患者对非交叉反应性HLA抗原选择性不匹配的血小板仍能持续产生令人满意的反应。数据表明，与HLA - A2阳性的同种免疫患者相比，在供者 - 受者HLA抗原差异范围更广的情况下，可为HLA - A2阴性的同种免疫患者提供血小板输注支持。
