乳腺癌患者的循环免疫复合物
Circulating immune complexes in patients with breast cancer.
作者信息
Hoffken K, Meredith I D, Robins R A, Baldwin R W, Davies C J, Blamey R W
出版信息
Br Med J. 1977 Jul 23;2(6081):218-20. doi: 10.1136/bmj.2.6081.218.
Abstract
In a retrospective study in women with breast cancer circulating immune complex levels were measured by radioimmunoprecipitation with 125I-Clq. Before operation all the patients showed plasma immune complex levels significantly higher than those in controls. Twelve months after mastectomy patients identified clinicopathologically as having a good prognosis had almost normal levels of immune complexes. By contrast, patients with detectable dissemination on diagnosis or those who died within 22 months after mastectomy had significantly raised plasma levels. The tumour-specific nature of the immune complexes detected remains to be shown and suggestions about the applicability of this test not only for prognosis but also for monitoring the course of malignant diseases need to be confirmed by further investigations.
摘要
在一项针对乳腺癌女性患者的回顾性研究中，通过用125I-Clq进行放射免疫沉淀法来测定循环免疫复合物水平。术前，所有患者的血浆免疫复合物水平均显著高于对照组。乳房切除术后12个月，经临床病理诊断预后良好的患者免疫复合物水平几乎正常。相比之下，诊断时已有可检测到的播散的患者或乳房切除术后22个月内死亡的患者，其血浆水平显著升高。所检测到的免疫复合物的肿瘤特异性性质仍有待证实，关于该检测不仅用于预后评估，还用于监测恶性疾病病程的适用性的建议，需要通过进一步研究来确认。
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本文引用的文献
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Studies on cellular immunity and its serum mediated inhibition in Moloney-virus-induced mouse sarcomas.莫洛尼病毒诱导的小鼠肉瘤细胞免疫及其血清介导抑制作用的研究。
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Suggestive evidence that the "blocking antibodies" of tumor-bearing individuals may be antigen--antibody complexes.有提示性证据表明，荷瘤个体的“封闭抗体”可能是抗原-抗体复合物。
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