Cronin M J, Baker M A
Brain Res. 1977 Jun 17;128(3):461-72. doi: 10.1016/0006-8993(77)90171-8.
Responses of single neurons in the midbrain of cats anesthetized with chloral hydrate were studied during manipulations of midbrain temperature produced with a bilateral water-perfused thermode. Temperatures of the thermodes and the anterior hypothalamus were monitored while single neuron activity was recorded between the thermodes and correlated with the midbrain temperature. Q10's and thermal coefficients were calculated from the estimated temperature at the neuron itself. A surprisingly high percentage (72%) of the 72 neurons recorded in the caudal paramedian midbrain of 11 cats were thermoresponsive. Most of these were heat sensitive and exhibited a variety of frequency/temperature curves. Explorations of more rostral regions of the midbrain in 9 cats yielded only 18% thermoresponsive units out of the 99 neurons sampled. We suggest that the concentrated pool of warm-sensitive neurons in the caudal midbrain is part of an extensive system of brain stem thermosensors which are involved in establishing and controlling normal brain temperature.
在用双侧水灌注热电极调节中脑温度的过程中，研究了水合氯醛麻醉的猫中脑单个神经元的反应。在记录热电极与前下丘脑温度的同时，记录热电极之间的单个神经元活动，并将其与中脑温度相关联。根据神经元自身的估计温度计算Q10值和热系数。在11只猫的尾侧中脑旁正中区域记录的72个神经元中，有72%的神经元对温度变化有反应，这一比例惊人地高。其中大多数对热敏感，并呈现出各种频率/温度曲线。在9只猫的中脑更靠前的区域进行探索，在99个采样神经元中，只有18%的神经元对温度变化有反应。我们认为，尾侧中脑集中的温敏神经元池是脑干温度传感器广泛系统的一部分，该系统参与建立和控制正常脑温。
