Eden J A
Royal Hospital for Women, Sydney, New South Wales, Australia.
Drugs Aging. 1996 Feb;8(2):127-33. doi: 10.2165/00002512-199608020-00006.
The use of hormone replacement therapy (HRT) after breast cancer is controversial. For a minority of such women, menopausal symptoms such as hot flushes can be so severe as to compromise quality of life. Moderate doses of progestogens alone are an effective therapy for hot flushes in around two-thirds of patients and poorly absorbed topical estrogens are well tolerated and effective for vaginal dryness. However, for a small number of women, the only effective therapy for hot flushes is estrogen replacement. Women with early stage breast cancer are unlikely to die from this disease and will be more likely to be affected by age-related diseases such as heart disease, strokes and osteoporotic fractures. These women may also benefit from estrogen replacement. Prospective trials are currently under way to determine the safety of HRT after breast cancer.
乳腺癌后使用激素替代疗法（HRT）存在争议。对于少数此类女性而言，潮热等更年期症状可能严重到影响生活质量。仅使用中等剂量的孕激素对约三分之二的患者的潮热是一种有效的治疗方法，而吸收较差的局部雌激素耐受性良好，对阴道干燥有效。然而，对于少数女性来说，潮热的唯一有效治疗方法是雌激素替代疗法。早期乳腺癌女性不太可能死于这种疾病，而更可能受心脏病、中风和骨质疏松性骨折等与年龄相关疾病的影响。这些女性也可能从雌激素替代疗法中获益。目前正在进行前瞻性试验以确定乳腺癌后HRT的安全性。
