Paterson M E
Br J Obstet Gynaecol. 1982 Jun;89(6):464-72. doi: 10.1111/j.1471-0528.1982.tb03638.x.
A randomized double-blind cross-over study into the effect of northisterone on climacteric symptoms was performed on 23 postmenopausal women. Active therapy resulted in a significant reduction in the number and severity of hot flushes and night sweats. There was also a slight improvement in memory, insomnia and lack of energy but the other climacteric symptoms were not consistently altered. Side effects were minimal. There was a significant reduction in serum calcium, alkaline phosphatase, cholesterol, triglycerides, follicle-stimulating hormone and luteinizing hormone levels. There was a variable effect on serum creatinine and urea but there was no significant alteration in the other biochemical profiles, liver-function tests, weight or blood pressure.
对23名绝经后女性进行了一项关于炔诺酮对更年期症状影响的随机双盲交叉研究。积极治疗使潮热和盗汗的次数及严重程度显著降低。记忆力、失眠和精力不足也有轻微改善，但其他更年期症状并未持续改变。副作用极小。血清钙、碱性磷酸酶、胆固醇、甘油三酯、促卵泡激素和促黄体生成素水平显著降低。对血清肌酐和尿素有不同影响，但其他生化指标、肝功能检查、体重或血压无显著变化。
