Tholin K, Sandström B, Palm R, Hallmans G
Department of Medicine, Ostersund Hospital, Sweden.
J Trace Elem Med Biol. 1995 Mar;9(1):13-7. doi: 10.1016/S0946-672X(11)80003-9.
Blood manganese levels and iron status indices were determined each trimester in 66 healthy pregnant women. Twenty-five were randomly assigned to iron supplementation, 19 to placebo and 22 received dietary advise aimed at increasing their dietary intake of fibre. Iron supplemented women had significantly higher levels of blood haemoglobin compared to the levels of the two other groups, and higher serum ferritin levels compared to the placebo group. No significant difference in blood manganese levels was observed among the three groups of women. There was a significant increase in blood manganese levels from one trimester to the next, which was slightly more pronounced in non supplemented women. The median values in the three trimesters were 154 (range 79-360) nmol/L, 190 (range 98-408) nmol/L, and 230 (range 133-481) nmol/L, respectively. Pregnancy seems to change manganese status or otherwise influence manganese metabolism irrespective of iron status and iron supplementation.
在66名健康孕妇中，每三个月测定一次血锰水平和铁状态指标。25名孕妇被随机分配接受铁补充剂，19名接受安慰剂，22名接受旨在增加膳食纤维摄入量的饮食建议。与其他两组相比，补充铁的孕妇血血红蛋白水平显著更高，与安慰剂组相比，血清铁蛋白水平更高。三组女性的血锰水平未观察到显著差异。从一个孕期到下一个孕期，血锰水平显著升高，在未补充铁的女性中这种升高更为明显。三个孕期的中位数分别为154（范围79 - 360）nmol/L、190（范围98 - 408）nmol/L和230（范围133 - 481）nmol/L。无论铁状态和铁补充情况如何，妊娠似乎都会改变锰状态或以其他方式影响锰代谢。
