缅甸的遗传性红细胞疾病与恶性疟的严重程度
Genetic red cell disorders and severity of falciparum malaria in Myanmar.
作者信息
Oo M, O'Sullivan W J
机构信息
Department of Medical Research, Ministry of Health, Yangon, Myanmar.
出版信息
Bull World Health Organ. 1995;73(5):659-65.
Abstract
A hospital-based survey was undertaken to investigate the relationship between the incidence and severity of malaria infection and various red cell disorders in Myanmar. The mean parasitaemia levels of patients with alpha- or beta-thalassaemia trait or with severe glucose-6-phosphate dehydrogenase (G6PD) deficiency were lower than those of individuals with normal haemoglobin AA or with heterozygous haemoglobin E. The double genetic defect of thalassaemia trait and severe G6PD deficiency appeared to confer some degree of protection against malaria.
摘要
在缅甸开展了一项基于医院的调查，以研究疟疾感染的发病率和严重程度与各种红细胞疾病之间的关系。患有α或β地中海贫血特征或严重葡萄糖-6-磷酸脱氢酶（G6PD）缺乏症的患者的平均疟原虫血症水平低于血红蛋白AA正常或血红蛋白E杂合的个体。地中海贫血特征和严重G6PD缺乏症的双重遗传缺陷似乎赋予了一定程度的抗疟疾保护作用。
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