Lumme A, Vanhatalo S, Soinila S
Department of Anatomy, University of Helsinki, Finland.
J Auton Nerv Syst. 1996 Jan 5;56(3):207-14. doi: 10.1016/0165-1838(95)00069-0.
By using mechanical nerve ligation or nerve pinch technique, we provide evidence that nitric oxide synthase (NOS) is transported in the preganglionic sympathetic axons, while postganglionic axons lack NOS transport. This finding corroborates the preganglionic sympathetic terminal as the site of NO synthesis, which is known to affect ganglionic transmission. Both vasoactive intestinal polypeptide (VIP) and substance P (SP) containing neurons of the nodose ganglion transport NOS in their axons. These results therefore suggest that NOergic innervation of autonomically innervated tissues is of parasympathetic and/or sensory, rather than sympathetic, origin.
通过使用机械性神经结扎或神经挤压技术，我们提供了证据表明一氧化氮合酶（NOS）在前交感神经节前轴突中运输，而后交感神经节后轴突缺乏NOS运输。这一发现证实了交感神经节前终末是一氧化氮合成的部位，已知一氧化氮会影响神经节传递。结状神经节中含有血管活性肠肽（VIP）和P物质（SP）的神经元在其轴突中运输NOS。因此，这些结果表明，自主神经支配组织的NO能神经支配起源于副交感神经和/或感觉神经，而非交感神经。
