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大肠杆菌mcb和emr操纵子的差异调控：mcb在多药耐药性中的作用

Differential regulation of the mcb and emr operons of Escherichia coli: role of mcb in multidrug resistance.

作者信息

Lomovskaya O, Kawai F, Matin A

机构信息

Department of Microbiology and Immunology, School of Medicine, Stanford University, California 94305, USA.

出版信息

Antimicrob Agents Chemother. 1996 Apr;40(4):1050-2. doi: 10.1128/AAC.40.4.1050.

DOI:10.1128/AAC.40.4.1050
PMID:8849229
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC163261/
Abstract

The mcb operon (which is responsible for microcin B17 production) and the emr operon (which encodes a multidrug resistance pump) share a common negative regulator, EmrR. Nevertheless, compounds that induce the emr operon repress the mcb operon. The pump dedicated to microcin B17 extrusion can also protect the calls against sparfloxacin and other toxic compounds.

摘要

mcb操纵子（负责微菌素B17的产生）和emr操纵子（编码一种多药耐药泵）共享一个共同的负调节因子EmrR。然而，诱导emr操纵子的化合物会抑制mcb操纵子。专门用于微菌素B17外排的泵也可以保护细胞免受司帕沙星和其他有毒化合物的侵害。

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本文引用的文献

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Posttranslational modifications in microcin B17 define an additional class of DNA gyrase inhibitor.微小菌素B17的翻译后修饰定义了一类新的DNA回旋酶抑制剂。
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EmrR is a negative regulator of the Escherichia coli multidrug resistance pump EmrAB.EmrR是大肠杆菌多药耐药泵EmrAB的负调控因子。
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mprA, an Escherichia coli gene that reduces growth-phase-dependent synthesis of microcins B17 and C7 and blocks osmoinduction of proU when cloned on a high-copy-number plasmid.mprA是大肠杆菌中的一个基因，当克隆到高拷贝数质粒上时，它会减少微菌素B17和C7的生长阶段依赖性合成，并阻断proU的渗透诱导。
J Bacteriol. 1990 Jan;172(1):437-45. doi: 10.1128/jb.172.1.437-445.1990.