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相似文献

1
In vitro model for natural tolerance to self-antigens. Inhibition of the development of surface-immunoglobulin-negative lymphocytes into T-dependent responsive B cells by antigen.自身抗原天然耐受的体外模型。抗原对表面免疫球蛋白阴性淋巴细胞发育为T细胞依赖性反应性B细胞的抑制作用。
J Exp Med. 1979 Aug 1;150(2):205-17. doi: 10.1084/jem.150.2.205.
2
Ontogenic development of B-lymphocyte function and tolerance susceptibility in vivo and in an in vitro organ culture system.体内及体外器官培养系统中B淋巴细胞功能的个体发生发展及耐受易感性
J Exp Med. 1980 Feb 1;151(2):429-45. doi: 10.1084/jem.151.2.429.
3
Tolerance induction in B lymphocytes but thymus-dependent antigens. T cells may abrogate B-cell tolerance induction by prevent an antibody response.B淋巴细胞对胸腺依赖性抗原的耐受性诱导。T细胞可能通过阻止抗体反应来消除B细胞的耐受性诱导。
J Exp Med. 1975 May 1;141(5):974-89. doi: 10.1084/jem.141.5.974.
4
Preventive effect of hapten-reactive thymus-derived helper lymphocytes on the tolerance induction in hapten-specific precursors of antibody-forming cells.半抗原反应性胸腺衍生辅助淋巴细胞对抗体形成细胞半抗原特异性前体细胞耐受性诱导的预防作用。
J Immunol. 1975 Jun;114(6):1771-8.
5
Membrane depolarization is induced in tolerant B lymphocytes by stimulation with antigen.在耐受性B淋巴细胞中，通过抗原刺激可诱导膜去极化。
Cell Immunol. 1986 Dec;103(2):417-25. doi: 10.1016/0008-8749(86)90101-2.
6
The in vitro induction of immunological tolerance in the B lymphocyte by oligovalent thymus-dependent antigens.多价胸腺依赖性抗原在体外诱导B淋巴细胞产生免疫耐受。
J Exp Med. 1975 May 1;141(5):962-73. doi: 10.1084/jem.141.5.962.
7
Effector cell blockade. A new mechanism of immune hyporeactivity induced by multivalent antigens.效应细胞阻断。一种由多价抗原诱导的免疫低反应性新机制。
J Exp Med. 1974 Jun 1;139(6):1582-98. doi: 10.1084/jem.139.6.1582.
8
Immunological tolerance in bone marrow-derived lymphocytes. II. Effects of allogeneic cell interactions and enzymatic digestion with trypsin or inactivated hapten-specific precursors of antibody-forming cells.骨髓来源淋巴细胞中的免疫耐受性。II. 同种异体细胞相互作用以及用胰蛋白酶或抗体形成细胞的无活性半抗原特异性前体进行酶消化的影响。
J Exp Med. 1974 Jun 1;139(6):1446-63. doi: 10.1084/jem.139.6.1446.
9
The characterization fo the B-cell repertoire specific for the 2,4-dinitrophenyl and 2,4,6-trinitrophenyl determinants in neonatal BALB/c mice.新生BALB/c小鼠中针对2,4-二硝基苯基和2,4,6-三硝基苯基决定簇的B细胞库特征分析
J Exp Med. 1975 May 1;141(5):1133-46. doi: 10.1084/jem.141.5.1133.
10
Murine B-cell subpopulations responsive to T-dependent and T-independent antigens.对T细胞依赖性和T细胞非依赖性抗原产生反应的小鼠B细胞亚群。
J Exp Med. 1976 Aug 1;144(2):382-97. doi: 10.1084/jem.144.2.382.

引用本文的文献

1
Autoimmune diseases: immunopathology and etiopathogenesis.自身免疫性疾病：免疫病理学与病因发病机制
Am J Pathol. 1982 Sep;108(3):319-65.
2
Clonal anergy: persistence in tolerant mice of antigen-binding B lymphocytes incapable of responding to antigen or mitogen.克隆无能：耐受小鼠体内存在对抗原或促有丝分裂原无反应的抗原结合B淋巴细胞。
Proc Natl Acad Sci U S A. 1980 Mar;77(3):1602-6. doi: 10.1073/pnas.77.3.1602.
3
Ontogenic development of B-lymphocyte function and tolerance susceptibility in vivo and in an in vitro organ culture system.体内及体外器官培养系统中B淋巴细胞功能的个体发生发展及耐受易感性
J Exp Med. 1980 Feb 1;151(2):429-45. doi: 10.1084/jem.151.2.429.
4
Long-term cultures of murine fetal liver retain very early B lymphoid phenotype.小鼠胎肝的长期培养保留了非常早期的B淋巴细胞表型。
J Exp Med. 1984 Oct 1;160(4):1087-101. doi: 10.1084/jem.160.4.1087.
5
Relationship between expression of IgA by Peyer's patch cells and functional IgA memory cells.派尔集合淋巴结细胞的IgA表达与功能性IgA记忆细胞之间的关系。
J Exp Med. 1987 Nov 1;166(5):1405-18. doi: 10.1084/jem.166.5.1405.
6
Comparison of the fetal and adult functional B cell repertoires by analysis of VH gene family expression.通过分析VH基因家族表达比较胎儿和成人功能性B细胞库。
J Exp Med. 1988 Aug 1;168(2):589-603. doi: 10.1084/jem.168.2.589.
7
Molecular analysis of neonatal IgA expression: implications for class switching, allelic polymorphism and somatic mutation.新生儿IgA表达的分子分析：对类别转换、等位基因多态性和体细胞突变的影响
Immunol Res. 1990;9(2):147-56. doi: 10.1007/BF02918205.

本文引用的文献

1
The induction of immunological tolerance in rats to foreign erythrocytes.大鼠对外源红细胞免疫耐受性的诱导。
Aust J Exp Biol Med Sci. 1958 Jun;36(3):235-44. doi: 10.1038/icb.1958.25.
2
Chemical and serological studies with an iodine-containing synthetic immunological determinant 4-hydroxy-3-iodo-5-nitrophenylacetic acid (NIP) and related compounds.对含碘合成免疫决定簇4-羟基-3-碘-5-硝基苯乙酸（NIP）及相关化合物的化学和血清学研究。
Immunology. 1966 May;10(5):465-79.
3
The separation of different cell classes from lymphoid organs. V. Simple procedures for the removal of cell debris. Damaged cells and erythroid cells from lymphoid cell suspensions.从淋巴器官中分离不同细胞类别。五、去除细胞碎片的简单程序。淋巴样细胞悬液中的受损细胞和红细胞。
J Immunol Methods. 1972 May;1(3):273-87. doi: 10.1016/0022-1759(72)90005-1.
4
The tolerant cell: direct evidence for receptor blockade by tolerogen.耐受细胞：耐受原对受体阻断的直接证据。
J Immunol. 1974 May;112(5):1793-803.
5
Autoimmunity in a rural community.农村社区的自身免疫
Clin Exp Immunol. 1972 Sep;12(1):79-87.
6
In vitro generation of B lymphocytes in mouse foetal liver, a mammalian 'bursa equivalent'.在小鼠胎肝（一种哺乳动物的“类腔上囊”）中进行B淋巴细胞的体外生成。
Nature. 1974 May 24;249(455):361-3. doi: 10.1038/249361a0.
7
Cell-to-cell interaction in the immune response. X. T-cell-dependent suppression in tolerant mice.免疫应答中的细胞间相互作用。X. 耐受小鼠中的T细胞依赖性抑制。
J Exp Med. 1974 Jul 1;140(1):199-217. doi: 10.1084/jem.140.1.199.
8
Mouse bone marrow lymphocytes and their differentiation.小鼠骨髓淋巴细胞及其分化
J Immunol. 1974 Sep;113(3):719-28.
9
Towards a network theory of the immune system.迈向免疫系统的网络理论。
Ann Immunol (Paris). 1974 Jan;125C(1-2):373-89.
10
Fate of antigen-binding cells in unresponsive and immune mice.无反应性和免疫小鼠中抗原结合细胞的命运
J Exp Med. 1973 Feb 1;137(2):461-9. doi: 10.1084/jem.137.2.461.

自身抗原天然耐受的体外模型。抗原对表面免疫球蛋白阴性淋巴细胞发育为T细胞依赖性反应性B细胞的抑制作用。

In vitro model for natural tolerance to self-antigens. Inhibition of the development of surface-immunoglobulin-negative lymphocytes into T-dependent responsive B cells by antigen.

作者信息

Teale J M, Layton J E, Nossal G J

出版信息

J Exp Med. 1979 Aug 1;150(2):205-17. doi: 10.1084/jem.150.2.205.

DOI:10.1084/jem.150.2.205
PMID:88498
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2185620/
Abstract

Neonatal and adult splenic cell suspensions were labeled with fluorescein isothiocynate-anti-Ig and fractionated into surface-immunoglobulin- (s-Ig) positive and s-Ig-negative subpopulations by the fluorescence-activated cell sorter. The subpopulations were then tested by splenic focus assay for both frequency and tolerance susceptibility of clonable 2,4,-dinitrophenol (DNP) precursors. It was shown that both adult, and neonatal, s-Ig-negative subsets contained clonable DNP-specific B-cell precursors. However, because these precursors result in fewer clones secreting IgG, they appeared to be less mature than the s-Ig-positive precursors. In the absence of helper T cells, it was found that exposure of s-Ig-negative lymphocytes to tolerogen during the process in which they were acquiring surface receptors resulted in nearly total abrogation of potential DNP clones. This finding provides compelling evidence for clonal abortion.

摘要

新生和成年脾细胞悬液用异硫氰酸荧光素 - 抗Ig进行标记，然后通过荧光激活细胞分选仪将其分为表面免疫球蛋白（s-Ig）阳性和s-Ig阴性亚群。接着，通过脾集落试验对可克隆的2,4 - 二硝基苯酚（DNP）前体细胞的频率和耐受性敏感性进行检测。结果显示，成年和新生的s-Ig阴性亚群均含有可克隆的DNP特异性B细胞前体。然而，由于这些前体产生的分泌IgG的克隆较少，它们似乎比s-Ig阳性前体成熟度更低。在没有辅助性T细胞的情况下，研究发现，s-Ig阴性淋巴细胞在获得表面受体的过程中暴露于致耐受原，会导致潜在的DNP克隆几乎完全消失。这一发现为克隆流产提供了有力证据。