3'-叠氮-3'-脱氧胸苷单磷酸（AZT）：一种AZT末端DNA外切核酸酶修复的抑制剂。
3'-azido-3'-deoxythymidine (AZT) monophosphate: an inhibitor of exonucleolytic repair of AZT-terminated DNA.
作者信息
Harrington J A, Reardon J E, Spector T
机构信息
Wellcome Research Laboratories, Burroughs Wellcome Co., Research Triangle Park, North Carolina 27709.
出版信息
Antimicrob Agents Chemother. 1993 Apr;37(4):918-20. doi: 10.1128/AAC.37.4.918.
A 3'-exonuclease(s) that excised 3'-azido-3'-deoxythymidine (AZT) monophosphate (AZTMP) from the 3' terminus of DNA was partially purified from two human cell lines. AZTMP inhibited the hydrolysis of AZTMP-terminated single-stranded and double-stranded DNA substrates. Thus, high levels of AZTMP might inhibit the exonuclease and trigger the toxicity of AZT by impairing the repair of AZTMP-terminated DNA.
从两个人类细胞系中部分纯化出一种3'-外切核酸酶，该酶能从DNA的3'末端切除3'-叠氮-3'-脱氧胸苷单磷酸（AZTMP）。AZTMP抑制了以AZTMP为末端的单链和双链DNA底物的水解。因此，高水平的AZTMP可能会抑制外切核酸酶，并通过损害以AZTMP为末端的DNA的修复来引发AZT的毒性。
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