Gao C, Abou-Nasr R, Norgren R B
Department of Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha 68198-6395, USA.
Brain Res Dev Brain Res. 1996 Feb 26;91(2):237-44. doi: 10.1016/0165-3806(95)00189-1.
LHRH neurons of the septal-preoptic area originate in the olfactory placode and migrate in the olfactory nerve into the brain during embryonic development. In adult birds, LHRH neurons have been found in the septal-preoptic area, mesencephalon and more recently in the lateral anterior nucleus of the thalamus (LA). LHRH neurons of the LA do not originate in the olfactory placode. Using immunocytochemistry, we examined the distribution of LHRH neurons in the embryonic and adult quail nervous system. The pattern of LHRH immunostaining in quail embryos was similar to that seen in chick embryos. However, there were many fewer neurons immunostained for LHRH from the olfactory placode to the septal-preoptic area in quail than in chick embryos. In contrast, there were more labeled neurons and more intense LHRH immunostaining in the thalamus of the quail than in the thalamus of chick embryos. In agreement with other studies, our data suggest that there are species differences in LHRH expression in migrating neurons. The current results should also be considered for quail-chick chimeras involving the olfactory placode.
隔区-视前区的促性腺激素释放激素（LHRH）神经元起源于嗅基板，并在胚胎发育期间沿嗅神经迁移至脑内。在成年鸟类中，已在隔区-视前区、中脑以及最近在丘脑外侧前核（LA）发现了LHRH神经元。LA的LHRH神经元并非起源于嗅基板。我们运用免疫细胞化学方法，研究了促性腺激素释放激素（LHRH）神经元在胚胎期和成年鹌鹑神经系统中的分布情况。鹌鹑胚胎中LHRH免疫染色的模式与鸡胚胎中所见相似。然而，从嗅基板到隔区-视前区，鹌鹑中LHRH免疫染色的神经元数量比鸡胚胎中的少得多。相反，鹌鹑丘脑中标记的神经元更多，LHRH免疫染色也比鸡胚胎丘脑中更强。与其他研究一致，我们的数据表明，迁移神经元中LHRH的表达存在物种差异。对于涉及嗅基板的鹌鹑-鸡嵌合体，也应考虑当前的研究结果。
