Wolf S E, Barrow R E, Herndon D N
Shiners Burns Institute, Galveston Unit, TX 77550, USA.
Baillieres Clin Endocrinol Metab. 1996 Jul;10(3):447-63. doi: 10.1016/s0950-351x(96)80575-1.
The use of exogenous GH to increase its circulating concentration, may benefit critically ill patients by increasing their nitrogen retention and promoting the wound healing process. GH also changes protein production in wounds, causes higher levels of insulin and changes substrate utilization. Its effects are anabolic, diabetogenic and lipolytic, acting through both direct and indirect mechanisms. The effects on carbohydrate and fat metabolism are directly mediated through specific GH receptors, while its effect on protein is mediated through IGF-I. Its effects on IGF-I production and the induction of IGF binding proteins are currently being studied in an effort to better understand the mechanism of GH actions during stress.
使用外源性生长激素（GH）来提高其循环浓度，可能通过增加氮潴留和促进伤口愈合过程，使危重症患者受益。生长激素还会改变伤口中的蛋白质生成，导致胰岛素水平升高并改变底物利用。其作用具有合成代谢、致糖尿病和脂解作用，通过直接和间接机制发挥作用。对碳水化合物和脂肪代谢的影响是通过特定的生长激素受体直接介导的，而其对蛋白质的影响则是通过胰岛素样生长因子-I（IGF-I）介导的。目前正在研究其对IGF-I生成和IGF结合蛋白诱导的影响，以便更好地了解应激期间生长激素作用的机制。
