Wolpert L
Department of Anatomy and Developmental Biology, University College, London, UK.
Trends Genet. 1996 Sep;12(9):359-64. doi: 10.1016/s0168-9525(96)80019-9.
One mechanism by which spatial patterns of cell differentiation could be specified during embryonic development and regeneration is based on positional information. Cells acquire a positional value with respect to boundaries and then interpret this in terms of a programme determined by their genetic constitution and developmental history. The signals and the molecular basis of such a system have both been rather well conserved. Recent work has shown that cells can respond to quite small differences in the concentrations of molecules whose concentration could provide positional information.
在胚胎发育和再生过程中，细胞分化的空间模式得以确定的一种机制是基于位置信息。细胞相对于边界获得一个位置值，然后根据由其遗传构成和发育历史所决定的程序来解读这个位置值。这样一个系统的信号和分子基础都得到了相当好的保留。最近的研究表明，细胞能够对那些其浓度可提供位置信息的分子浓度的相当小的差异做出反应。
