Hoekstra J H, van den Aker J H
Division of Paediatrics, Bosch Medicentrum, 's-Hertogenbosch, The Netherlands.
J Pediatr Gastroenterol Nutr. 1996 Aug;23(2):118-24. doi: 10.1097/00005176-199608000-00004.
The facilitating effect of glucose on free fructose absorption has been suggested to be due to a sucrase-related transport mechanism. In contrast, the conditions influencing the absorption of sorbitol have hardly been investigated. As amino acids promote transcellular water flow, we investigated their effects on the absorption of fructose and sorbitol. We studied 15 healthy children using breath hydrogen tests following the ingestion of fructose and sorbitol, alone and in combination with glucose or amino acids. Similarly, the effect of acarbose pretreatment on sucrose and fructose-glucose absorption was investigated. The inhibition of sucrase isomaltase by acarbose impedes the absorption of sucrose but not of the fructose-glucose mixture. Fructose absorption is enhanced by glucose and by the amino acids L-alanine, L-glutamine, L-phenylalanine, and L-proline. Similarly, the absorption of sorbitol is facilitated by glucose and L-alanine. These results are not in concordance with a sucrase-related fructose-transport system and suggest another mechanism for glucose-induced enhancement of fructose (and sorbitol) absorption. We hypothesize that the absorption of fructose and sorbitol may be stimulated by the increased water flux induced by active absorption of glucose as well as amino acids.
葡萄糖对游离果糖吸收的促进作用被认为是由于一种与蔗糖酶相关的转运机制。相比之下，影响山梨醇吸收的条件几乎未被研究。由于氨基酸可促进跨细胞水流，我们研究了它们对果糖和山梨醇吸收的影响。我们对15名健康儿童进行了研究，在他们摄入果糖和山梨醇单独以及与葡萄糖或氨基酸联合的情况下，采用呼气氢试验。同样，研究了阿卡波糖预处理对蔗糖和果糖 - 葡萄糖吸收的影响。阿卡波糖对蔗糖酶异麦芽糖酶的抑制作用会阻碍蔗糖的吸收，但不会影响果糖 - 葡萄糖混合物的吸收。果糖的吸收会因葡萄糖以及L - 丙氨酸、L - 谷氨酰胺、L - 苯丙氨酸和L - 脯氨酸等氨基酸而增强。同样，葡萄糖和L - 丙氨酸可促进山梨醇的吸收。这些结果与一种与蔗糖酶相关的果糖转运系统不一致，并提示了葡萄糖诱导的果糖（和山梨醇）吸收增强的另一种机制。我们推测，果糖和山梨醇的吸收可能受到葡萄糖以及氨基酸主动吸收所诱导的水通量增加的刺激。
