Soltys J, Borosková Z, Dubinský P, Tomasovicová O, Auer H, Aspöck H
Parasitological Institute (SAS), Kosice, Slovak Republic.
Appl Parasitol. 1996 Sep;37(3):161-7.
Glucan immunomodulator, combined with immunoglobulin and zinc (GI), was tested in mice infected with Toxocara canis for its effects on the immune response and parasite recovery. Infection with 2 500 T. canis eggs per mouse induced a short-term depression of the proliferative response of T cells to phytohemaglutinin from Day 35 to a Day 49 post infection (p.i.). GI given in two doses at the start of the experiment markedly stimulated and restored cell proliferation at Days 21-63 p.i. Infection resulted in significant increase in specific circulating antibody level at Days 21 and 35 p.i. A striking reduction in the number of T. canis larvae, after GI administration was observed in the muscles of the GI-treated mice, compared with the untreated animals.
葡聚糖免疫调节剂与免疫球蛋白和锌（GI）联合使用，在感染犬弓首蛔虫的小鼠中测试了其对免疫反应和寄生虫清除的影响。每只小鼠感染2500个犬弓首蛔虫卵后，从感染后第35天到第49天，T细胞对植物血凝素的增殖反应出现短期抑制。在实验开始时给予两剂GI，在感染后第21 - 63天显著刺激并恢复了细胞增殖。感染导致在感染后第21天和第35天特异性循环抗体水平显著升高。与未治疗的动物相比，在接受GI治疗的小鼠肌肉中观察到，给予GI后犬弓首蛔虫幼虫数量显著减少。
