Reinemer H C, Wilson C F, Webb M D
Department of Pediatric Dentistry, Baylor College of Dentistry, Dallas, Texas, USA.
Pediatr Dent. 1996 Jul-Aug;18(4):294-300.
This double-blind, crossover study assessed physiology and behaviour following administration of two oral ketamine-diazepam sedation regimens (4 mg/kg and 8 mg/ kg ketamine in conjunction with 0.1 mg/kg diazepam). Clinical success was achieved in 50% of sedations with 4 mg/kg and 78% of sedations with 8 mg/kg with no significant differences between the two regimens (Fisher's exact test). Within the crossover group, clinical success was achieved in 56% of sedations with 4 mg/kg and 87% of sedations with 8 mg/kg with no significant differences between the two regimens (Fisher's exact). Although clinically insignificant, ANOVA revealed statistical elevations in blood pressures and heart rates and decreases in oxygen saturations (P < 0.05). The 4-mg/kg regimen resulted in more negative behavior and less sleep. The 8-mg/kg regimen resulted in less negative behavior and more sleep.
这项双盲交叉研究评估了两种口服氯胺酮 - 地西泮镇静方案（4毫克/千克和8毫克/千克氯胺酮联合0.1毫克/千克地西泮）给药后的生理和行为情况。4毫克/千克组50%的镇静操作取得临床成功，8毫克/千克组78%的镇静操作取得临床成功，两组方案之间无显著差异（Fisher精确检验）。在交叉组中，4毫克/千克组56%的镇静操作取得临床成功，8毫克/千克组87%的镇静操作取得临床成功，两组方案之间无显著差异（Fisher精确检验）。尽管临床意义不大，但方差分析显示血压和心率有统计学上的升高，血氧饱和度下降（P < 0.05）。4毫克/千克方案导致更多负面行为和更少睡眠。8毫克/千克方案导致更少负面行为和更多睡眠。
