Khosla Uday, Ruel Kelly S, Hunt Daniel P
Department of Internal Medicine, Baylor College of Medicine, Houston, TX, USA.
South Med J. 2003 Oct;96(10):1023-6. doi: 10.1097/01.SMJ.0000076461.67623.E4.
Antihistamines, which are readily available over the counter in sleeping aids, are commonly found in intentional overdoses. We report three new cases of severe rhabdomyolysis related to ingestion of these agents. This is a rarely reported but potentially overlooked complication among patients who present to the emergency center after intentional overdoses. We also describe the potential mechanism of muscle injury in antihistamine overdoses and comment on the potential for cross-reactivity of antihistamines with the urine screen for phencyclidine.
抗组胺药在非处方睡眠辅助药物中很常见，在故意过量服用的情况中也很常见。我们报告了3例与这些药物摄入相关的严重横纹肌溶解新病例。这是一种在故意过量服药后到急诊中心就诊的患者中很少报道但可能被忽视的并发症。我们还描述了抗组胺药过量导致肌肉损伤的潜在机制，并对抗组胺药与苯环利定尿液筛查的交叉反应可能性进行了评论。
