Frankel D, Dolgin J, Murray B M
Renal Division, Erie County Medical Center, Buffalo, NY 14215.
J Toxicol Clin Toxicol. 1993;31(3):493-6. doi: 10.3109/15563659309000418.
Antihistamines are common over the counter medications which are frequently involved in overdoses. The usual clinical course is dominated by the anticholinergic affects of these agents; it includes significant autonomic and central nervous system effects and direct cardiac toxicity (1). We report a case of a suicide attempt in a young adult male where ingestion of the antihistamines diphenhydramine and doxylamine was complicated by non-traumatic rhabdomyolysis and acute renal failure.
抗组胺药是常见的非处方药，经常会出现过量服用的情况。这些药物的常规临床病程以抗胆碱能作用为主；包括显著的自主神经系统和中枢神经系统作用以及直接的心脏毒性（1）。我们报告一例年轻成年男性自杀未遂病例，该患者因摄入抗组胺药苯海拉明和多西拉敏而并发非创伤性横纹肌溶解症和急性肾衰竭。
