环丙沙星、氧氟沙星和庆大霉素局部给药后在兔眼炎症组织中的吸收情况。
Absorption of topically administered ciprofloxacin, ofloxacin and gentamicin in the inflamed rabbit eye.
作者信息
Behrens-Baumann W
机构信息
Universitats-Augenklinik der Otto-von-Guericke-Universitat Magdeburg, Deutschland.
出版信息
Ophthalmologica. 1996;210(2):119-22. doi: 10.1159/000310687.
PMID:8859488
Abstract
The authors evaluated the ocular absorption of ciprofloxacin, ofloxacin and gentamicin as a reference drug in a novel model of ocular inflammation. The ocular absorption of ciprofloxacin and ofloxacin was shown to be increased two- to threefold in the inflamed eye. The absorption of gentamicin was undetectable in the normal eye and very poor in the inflamed eye.
摘要
作者在一种新型眼部炎症模型中评估了环丙沙星、氧氟沙星以及作为参比药物的庆大霉素的眼部吸收情况。结果显示，环丙沙星和氧氟沙星在发炎眼睛中的眼部吸收增加了两到三倍。在正常眼睛中未检测到庆大霉素的吸收，在发炎眼睛中的吸收也非常差。
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