• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

环丙沙星、氧氟沙星和庆大霉素局部给药后在兔眼炎症组织中的吸收情况。

Absorption of topically administered ciprofloxacin, ofloxacin and gentamicin in the inflamed rabbit eye.

作者信息

Behrens-Baumann W

机构信息

Universitats-Augenklinik der Otto-von-Guericke-Universitat Magdeburg, Deutschland.

出版信息

Ophthalmologica. 1996;210(2):119-22. doi: 10.1159/000310687.

DOI:10.1159/000310687
PMID:8859488
Abstract

The authors evaluated the ocular absorption of ciprofloxacin, ofloxacin and gentamicin as a reference drug in a novel model of ocular inflammation. The ocular absorption of ciprofloxacin and ofloxacin was shown to be increased two- to threefold in the inflamed eye. The absorption of gentamicin was undetectable in the normal eye and very poor in the inflamed eye.

摘要

作者在一种新型眼部炎症模型中评估了环丙沙星、氧氟沙星以及作为参比药物的庆大霉素的眼部吸收情况。结果显示,环丙沙星和氧氟沙星在发炎眼睛中的眼部吸收增加了两到三倍。在正常眼睛中未检测到庆大霉素的吸收,在发炎眼睛中的吸收也非常差。

相似文献

1
Absorption of topically administered ciprofloxacin, ofloxacin and gentamicin in the inflamed rabbit eye.环丙沙星、氧氟沙星和庆大霉素局部给药后在兔眼炎症组织中的吸收情况。
Ophthalmologica. 1996;210(2):119-22. doi: 10.1159/000310687.
2
[Corneal penetration of various aminoglycosides and quinolones].[各种氨基糖苷类和喹诺酮类药物的角膜穿透性]
Klin Monbl Augenheilkd. 1998 Sep;213(3):141-6. doi: 10.1055/s-2008-1034964.
3
Improved penetration of aminoglycosides and fluorozuinolones into the aqueous humour of patients by means of Acuvue contact lenses.通过Acuvue隐形眼镜提高氨基糖苷类药物和氟喹诺酮类药物在患者房水中的渗透率。
Eur J Clin Pharmacol. 1999 Jun;55(4):317-23. doi: 10.1007/s002280050635.
4
Penetration of ciprofloxacin, norfloxacin and ofloxacin into the aqueous humor using different topical application modes.使用不同局部应用方式时环丙沙星、诺氟沙星和氧氟沙星在房水中的渗透情况。
Graefes Arch Clin Exp Ophthalmol. 1999 Feb;237(2):89-92. doi: 10.1007/s004170050200.
5
Treatment of experimental bacterial keratitis with topical trovafloxacin.局部用曲伐沙星治疗实验性细菌性角膜炎。
Arch Ophthalmol. 2004 Jan;122(1):65-9. doi: 10.1001/archopht.122.1.65.
6
Aqueous humor penetration of topically applied ciprofloxacin, ofloxacin and tobramycin.局部应用环丙沙星、氧氟沙星和妥布霉素的房水通透性。
Arzneimittelforschung. 1997 Apr;47(4):413-5.
7
Penetration of ofloxacin and ciprofloxacin in aqueous humor after topical administration.局部给药后氧氟沙星和环丙沙星在房水中的渗透情况。 (注:原文中“Penetration of ofloxacin and ciprofloxacin in aqueous humor after topical administration.”里多了一个“of”)
Ophthalmic Surg Lasers. 1999 Jun;30(6):465-8.
8
Aqueous humour levels of topically applied ciprofloxacin and ofloxacin in the same subjects.同一受试者局部应用环丙沙星和氧氟沙星后的房水浓度。
Eye (Lond). 1999 Oct;13 ( Pt 5):656-9. doi: 10.1038/eye.1999.178.
9
Effect of a novel mucoadhesive polysaccharide obtained from tamarind seeds on the intraocular penetration of gentamicin and ofloxacin in rabbits.从罗望子种子中提取的一种新型黏附性多糖对庆大霉素和氧氟沙星在兔眼内渗透性的影响。
J Antimicrob Chemother. 2000 Nov;46(5):831-4. doi: 10.1093/jac/46.5.831.
10
Penetration of topically applied ciprofloxacin and ofloxacin into the aqueous humor and vitreous.局部应用的环丙沙星和氧氟沙星在房水和玻璃体中的渗透情况。
J Cataract Refract Surg. 2003 Mar;29(3):487-91. doi: 10.1016/s0886-3350(02)01538-9.

引用本文的文献

1
Kinetics of Fluorescein in Tear Film After Eye Drop Instillation in Beagle Dogs: Does Size Really Matter?比格犬滴眼后泪膜中荧光素的动力学:大小真的重要吗?
Front Vet Sci. 2019 Dec 19;6:457. doi: 10.3389/fvets.2019.00457. eCollection 2019.
2
Pharmacokinetics and aqueous humor penetration of levofloxacin 1.5% and moxifloxacin 0.5% in patients undergoing cataract surgery.左氧氟沙星1.5%和莫西沙星0.5%在白内障手术患者中的药代动力学及房水渗透情况
Clin Ophthalmol. 2016 May 2;10:783-9. doi: 10.2147/OPTH.S91286. eCollection 2016.
3
Lens concentration of ofloxacin and lomefloxacin in an experimental endophthalmitis model.
实验性眼内炎模型中氧氟沙星和洛美沙星的晶状体浓度。
Curr Ther Res Clin Exp. 2007 May;68(3):184-90. doi: 10.1016/j.curtheres.2007.06.003.
4
Penetration of topical, oral, and combined administered ofloxacin into the subretinal fluid.局部、口服及联合给药的氧氟沙星在视网膜下液中的渗透情况。
Br J Ophthalmol. 1999 Oct;83(10):1183-5. doi: 10.1136/bjo.83.10.1183.