Crofford L J, Demitrack M A
Department of Internal Medicine, University of Michigan, Ann Arbor, USA.
Rheum Dis Clin North Am. 1996 May;22(2):267-84. doi: 10.1016/s0889-857x(05)70272-6.
Fibromyalgia (FM) and chronic fatigue syndrome (CFS) fall into the spectrum of what might be termed stress-associated syndromes by virtue of frequent onset after acute or chronic stressors and apparent exacerbation of symptoms during periods of physical or emotional stress. These illnesses also share perturbation of the hypothalamic-pituitary-adrenal axis and sympathetic stress response systems. In this article, the authors discuss the specific neurohormonal abnormalities found in FM and CFS and potential mechanisms by which dysfunction of neurohormonal stress-response systems could contribute to vulnerability to stress-associated syndromes and to the symptoms of FM and CFS.
纤维肌痛（FM）和慢性疲劳综合征（CFS）属于可能被称为应激相关综合征的范畴，因为它们常在急性或慢性应激源后频繁发病，且在身体或情绪应激期间症状明显加重。这些疾病还存在下丘脑 - 垂体 - 肾上腺轴和交感神经应激反应系统的紊乱。在本文中，作者讨论了在纤维肌痛和慢性疲劳综合征中发现的特定神经激素异常，以及神经激素应激反应系统功能障碍可能导致易患应激相关综合征以及纤维肌痛和慢性疲劳综合征症状的潜在机制。
