红果金丝桃中的呫吨酮类化合物。

Xanthones from Hypericum roeperanum.

作者信息

Rath G, Potterat O, Mavi S, Hostettmann K

机构信息

Institut de Pharmacognosie et Phytochimie, Université de Lausanne, Switzerland.

出版信息

Phytochemistry. 1996 Sep;43(2):513-20. doi: 10.1016/0031-9422(96)00284-1.

DOI:10.1016/0031-9422(96)00284-1

PMID:8862040

Abstract

Four new xanthones have been isolated from the roots of Hypericum roeperanum. Their structures have been established by a combination of spectroscopic and chemical methods as 1,6-dihydroxy-5-methoxy-4',5'-dihydro-4',4',5'-trimethylfurano- (2',3':3,4)-xanthone (5-O-methyl-2-deprenylrheediaxanthone B), 1,6-dihydroxy-5-methoxy-6',6'-dimethylpyrano-(2',3':3,4)-xanthone (5-O-methylisojacareubin), 1,3,5,6-tetrahydroxy-2-(2',2'-dimethyl-4'-isopropenyl)-cyclopen tanylxanthone (5-O-demethylpaxanthonin) and 1,3,5,6-tetrahydroxy-4-trans-sesquilavandulylxanthone (roeperanone). In addition, 2-hydroxyxanthone, 5-hydroxy-2-methoxyxanthone, 1,5-dihydroxy-2-methoxyxanthone, 2-deprenyl rheediaxanthone B, isojacareubin and calycinoxanthone D have been isolated and characterized. Some of the isolated xanthones exhibited antifungal activity against Candida albicans.

摘要

从多蕊金丝桃的根部分离出了四种新的呫吨酮。通过光谱和化学方法相结合确定了它们的结构，分别为1,6 - 二羟基 - 5 - 甲氧基 - 4',5'- 二氢 - 4',4',5'- 三甲基呋喃并 - (2',3':3,4)- 呫吨酮（5 - O - 甲基 - 2 - 去甲异戊二烯基红厚壳呫吨酮B）、1,6 - 二羟基 - 5 - 甲氧基 - 6',6'- 二甲基吡喃并 - (2',3':3,4)- 呫吨酮（5 - O - 甲基异巴西红厚壳素）、1,3,5,6 - 四羟基 - 2 - (2',2'- 二甲基 - 4'- 异丙烯基) - 环戊烷基呫吨酮（5 - O - 去甲基帕呫吨酮）和1,3,5,6 - 四羟基 - 4 - 反式 - 倍半薰衣草基呫吨酮（多蕊金丝桃呫吨酮）。此外，还分离并鉴定了2 - 羟基呫吨酮、5 - 羟基 - 2 - 甲氧基呫吨酮、1,5 - 二羟基 - 2 - 甲氧基呫吨酮、2 - 去甲异戊二烯基红厚壳呫吨酮B、异巴西红厚壳素和卡利西诺呫吨酮D。部分分离出的呫吨酮对白色念珠菌表现出抗真菌活性。