Yodfat Y, Silvian I
J Infect Dis. 1977 Jul;136(1):26-30. doi: 10.1093/infdis/136.1.26.
Absolute concentrations of IgA in nasal secretions and concentrations of immunoglobulins in serum were determined in a prospective study of acute respiratory tract infections. The study was carried out in 48 children aged six months to four years liveing in a kibbutz with a homogeneous environment. No correlation was demonstrated between mean base-line levels of secretory IgA or serum IgA and number of episodes of acute resporatory tract infection. However, children who responded to infection by the production of higher levels of secretory IgA had a lower incidence of acute respiratory tract infection than those who did not. Thisfinding supports the hypothesis that the responsiveness of the host in the production of secretory IgA during infection is important in protection against mucosal infections.
在一项关于急性呼吸道感染的前瞻性研究中，测定了鼻分泌物中IgA的绝对浓度以及血清中免疫球蛋白的浓度。该研究在一个环境同质化的集体农场中对48名年龄在6个月至4岁的儿童进行。分泌型IgA或血清IgA的平均基线水平与急性呼吸道感染发作次数之间未显示出相关性。然而，感染时产生较高水平分泌型IgA的儿童，其急性呼吸道感染的发病率低于未产生较高水平分泌型IgA的儿童。这一发现支持了这样的假设，即宿主在感染期间分泌型IgA产生的反应性对于预防黏膜感染很重要。
