Germann D, Ströhle A, Eggenberger K, Steiner C A, Matter L
Institute of Medical Microbiology, University of Bern, Switzerland.
Scand J Infect Dis. 1996;28(3):235-8. doi: 10.3109/00365549609027163.
Since 1991, 6 years after the recommendation of universal childhood triple vaccination against measles, mumps and rubella (M + M + R), Switzerland has been confronted with an increasing number of mumps cases affecting both vaccinated and unvaccinated children. The M + M + R vaccine mainly used in the Swiss population after 1986 contains the highly attenuated Rubini strain of mumps virus. We analysed an outbreak of 102 suspected mumps cases by virus isolation, determination of IgM antibodies to mumps virus in 27 acute phase sera, and verification of vaccination histories. Mumps was confirmed by virus isolation in 88 patients, of whom 72 had previously received the Rubini vaccine strain. IgM antibodies to mumps virus were detected in 24/27 acute phase serum samples. A group of 92 subjects from the same geographic area without signs of mumps virus infection served as controls. IgG antibodies to mumps virus and vaccination status were assessed in these children. The vaccination rate in these controls was 61%, with equal seropositivity for unvaccinated and Rubini-vaccinated subjects. These data support other recent reports which indicate an insufficient protective efficacy of current mumps vaccines.
自1991年起，即在推荐对儿童普遍进行麻疹、腮腺炎和风疹三联疫苗接种（M+M+R）6年后，瑞士面临着越来越多的腮腺炎病例，接种疫苗和未接种疫苗的儿童均受影响。1986年后瑞士人群主要使用的M+M+R疫苗含有高度减毒的腮腺炎病毒鲁宾株。我们通过病毒分离、检测27份急性期血清中针对腮腺炎病毒的IgM抗体以及核查疫苗接种史，对102例疑似腮腺炎病例的疫情进行了分析。88例患者通过病毒分离确诊为腮腺炎，其中72例之前接种过鲁宾疫苗株。在27份急性期血清样本中有24份检测到针对腮腺炎病毒的IgM抗体。来自同一地理区域的92名无腮腺炎病毒感染迹象的受试者作为对照。对这些儿童评估了针对腮腺炎病毒的IgG抗体和疫苗接种状况。这些对照中的疫苗接种率为61%，未接种疫苗和接种鲁宾疫苗的受试者血清阳性率相同。这些数据支持了最近的其他报告，这些报告表明当前腮腺炎疫苗的保护效力不足。
