Scheibel R S, Meyers C A, Levin V A
Department of Psychiatry, University of California, Los Angeles, USA.
J Neurooncol. 1996 Oct;30(1):61-9. doi: 10.1007/BF00177444.
This study examined the relationship between cognitive function, tumor malignancy, adjunctive therapy, and lesion lateralization following surgery for intracerebral glioma. Neuropsychological test battery results showed no difference between patients with highly malignant gliomas and those with less malignant gliomas, but differences were found for tumor lateralization and type of therapy. Scores on a test of graphomotor speed were lowest for patients who had received radiation or a combination of radiation and chemotherapy, regardless of lesion location. Other test results did not differ according to type of prior treatment but were related instead to tumor lateralization. Left hemisphere lesions were associated with lower scores on verbal tests, while right hemisphere lesions were related to lower scores on a test of facial recognition. These findings suggest that neuropsychological tests may be useful for distinguishing between the diffuse side effects of brain tumor therapy and the focal effects of tumors and surgery on brain functions. In addition, it appears that any differences in cognitive function due to tumor malignancy are eliminated or reduced following surgical intervention.
本研究探讨了脑胶质瘤手术后认知功能、肿瘤恶性程度、辅助治疗及病变侧别之间的关系。神经心理测试组结果显示，高度恶性胶质瘤患者与低度恶性胶质瘤患者之间无差异，但在肿瘤侧别和治疗类型方面存在差异。无论病变位置如何，接受放疗或放疗与化疗联合治疗的患者在书写运动速度测试中的得分最低。其他测试结果根据先前治疗类型并无差异，而是与肿瘤侧别相关。左半球病变与言语测试得分较低相关，而右半球病变与面部识别测试得分较低相关。这些发现表明，神经心理测试可能有助于区分脑肿瘤治疗的弥漫性副作用与肿瘤及手术对脑功能的局灶性影响。此外，似乎手术干预后因肿瘤恶性程度导致的认知功能差异会被消除或减少。
