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[利尿剂治疗充血性循环功能不全时血液流变学特性的变化]

[Change in rheographic properties of blood in congestive circulatory insufficiency treated with diuretics].

作者信息

Savenkov M P

出版信息

Kardiologiia. 1977 May;17(5):52-7.

PMID:886752
Abstract

Proceeding from a dynamic study of the rheological properties of blood in 85 patients with stage II-III congestive circulatory insufficiency treated with diuretics (Furosemid, Hypothiazid, Uregit, Verospiron) a conclusion is made that a rational employment of diuretic agents does not result in any increase in blood concentration, and does not increase the risk of thrombotic complications. On the contrary, in some patients with stage IIB-III circulatory insufficiency some normalization of the rheological properties of blood, that had been impaired before the treatment, was noted. The use of diuretics only moderately increased the hematocrit and blood viscosity values, but decreased the aggregation of the erythrocytes and platelets. The improvement of the rheological properties of blood was attributed to the normalization of the water-electrolyte disorders that the patients had had. In cases in which thrombotic complications occurred a low hematocrit and blood viscosity level was common, while the erythrocytes and platelets aggregation was increased.

摘要

通过对85例接受利尿剂(速尿、氢氯噻嗪、乌利吉特、螺内酯)治疗的II - III期充血性循环功能不全患者的血液流变学特性进行动态研究,得出结论:合理使用利尿剂不会导致血液浓度升高,也不会增加血栓形成并发症的风险。相反,在一些IIB - III期循环功能不全的患者中,注意到治疗前受损的血液流变学特性出现了一定程度的正常化。利尿剂的使用仅适度增加了血细胞比容和血液粘度值,但降低了红细胞和血小板的聚集。血液流变学特性的改善归因于患者水 - 电解质紊乱的正常化。在发生血栓形成并发症的病例中,血细胞比容和血液粘度水平通常较低,而红细胞和血小板聚集增加。

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