Bobek P, Ozdín O, Mikus M
Research Institute of Nutrition, Bratislava, Slovak Republic.
Physiol Res. 1995;44(5):287-91.
The effect of adding 5% powdered oyster mushroom (Pleurotus ostreatus) during 12 weeks on kinetic parameters of cholesterol metabolism was studied in male rats (Wistar, initial body weight 85 g) fed a semisynthetic diet containing 0.3% of cholesterol. The plasma cholesterol decay curve (examined for the final 29 days of the experiment after a single dose of cholesterol-4-14C) was evaluated by mathematical analysis using a two-pool model of plasma cholesterol metabolism. The oyster mushroom in the diet reduced the half-times of both exponentials resulting in lower calculated values (by 28%) of total entry of cholesterol into the body cholesterol pool (absorption+endogenous synthesis) and lower sizes of both pools (with slower and faster cholesterol exchange). The rate of cholesterol exchange between the pools was enhanced and the rate of total clearance of cholesterol from the system (metabolic turnover rate of cholesterol i.e. the rate of degradation and excretion of cholesterol from the organism) was enhanced by 50%. The oyster mushroom diet effectively prevented the progress of hypercholesterolaemia (decrease by 38%) and cholesterol accumulation in liver (decrease by 25%) that were induced by the cholesterol diet.
在喂食含0.3%胆固醇的半合成饲料的雄性大鼠（Wistar，初始体重85克）中，研究了在12周期间添加5%平菇粉（糙皮侧耳）对胆固醇代谢动力学参数的影响。通过使用血浆胆固醇代谢的双池模型进行数学分析，评估血浆胆固醇衰减曲线（在单剂量胆固醇-4-14C后，在实验的最后29天进行检测）。饮食中的平菇降低了两个指数的半衰期，导致计算得出的胆固醇进入体内胆固醇池的总摄入量（吸收+内源性合成）较低值（降低28%），以及两个池的大小较小（胆固醇交换较慢和较快）。池之间的胆固醇交换速率提高，系统中胆固醇的总清除率（胆固醇的代谢周转率，即胆固醇从生物体降解和排泄的速率）提高了50%。平菇饮食有效预防了由胆固醇饮食引起的高胆固醇血症进展（降低38%）和肝脏中胆固醇积累（降低25%）。
