Shimada Y, Kanda Y, Shibagaki I, Kato M, Watanabe G, Tanaka H, Kano M, Imamura M
First Department of Surgery, Kyoto University, Japan.
Br J Surg. 1996 Aug;83(8):1148-51. doi: 10.1002/bjs.1800830837.
The growth of primary cell cultures of oesophageal cancer was compared with the clinical outcome of patients from whom the cancers were taken. Ninety-three patients underwent curative resection, with no operative deaths, and were divided into three groups according to the monolayer culture pattern of the primary cell culture: culture from 43 patients (46 per cent) grew no malignant cells (group 1), 21 (23 per cent) produced monolayer epithelial growth (group 2) and the rest (from 29 patients) established cell lines (group 3). The 5-year survival rate of patients in group 2 (29 per cent) and group 3 (23 per cent) was significantly lower (P < 0.005) than that of those in group 1 (51 per cent). Monolayer epithelial growth potential is a significant prognostic factor in patients with oesophageal cancer.
将食管癌原代细胞培养的生长情况与取自这些癌症患者的临床结果进行了比较。93例患者接受了根治性切除，无手术死亡，并根据原代细胞培养的单层培养模式分为三组：43例患者（46%）的培养物未生长出恶性细胞（第1组），21例（23%）产生单层上皮生长（第2组），其余（来自29例患者）建立了细胞系（第3组）。第2组（29%）和第3组（23%）患者的5年生存率显著低于第1组（51%）（P<0.005）。单层上皮生长潜能是食管癌患者的一个重要预后因素。
