Binet A, Kooh S W
Department of Paediatrics, University of Toronto, Ontario.
Can J Public Health. 1996 Jul-Aug;87(4):227-30.
To assess the current picture of vitamin D deficiency, we reviewed all 17 cases of vitamin D-deficiency rikets seen in the referral clinic of a children's hospital in Toronto between 1988 and 1993. The diagnosis was made at 7 to 33 months of age. All the children were symptomatic all had biochemical and radiographic abnormalities, two suffered hypocalcemic seizures, and all had bowing of the extremities. Twelve of the children were born to parents who were recent immigrants to Canada. All were of Asian or African origin with dark skin. All the children had been exclusively breastfed with no vitamin D supplementation, and had had little or no sunlight exposure. All the patients responded to vitamin D therapy. We conclude that vitamin D-deficiency rickets remains an environmental/nutritional deficiency disease in this city and that efforts at prevention should target children with pigmented skin from families who are recent immigrants.
为评估维生素D缺乏症的现状，我们回顾了1988年至1993年间在多伦多一家儿童医院的转诊诊所中所见的17例维生素D缺乏性佝偻病病例。诊断时患儿年龄为7至33个月。所有患儿均有症状，均存在生化及影像学异常，2例发生低钙惊厥，所有患儿均有四肢弯曲。其中12名患儿的父母是近期移民到加拿大的。他们均来自亚洲或非洲，肤色较深。所有患儿均为纯母乳喂养，未补充维生素D，且很少或没有阳光照射。所有患者对维生素D治疗均有反应。我们得出结论，在本市维生素D缺乏性佝偻病仍然是一种环境/营养缺乏性疾病，预防措施应针对来自近期移民家庭、皮肤有色素沉着的儿童。
