Huh Susanna Y, Gordon Catherine M
Division of Gastroenterology and Nutrition, Children's Hospital Boston, Boston, MA 02115, USA.
Rev Endocr Metab Disord. 2008 Jun;9(2):161-70. doi: 10.1007/s11154-007-9072-y. Epub 2008 Jan 4.
Vitamin D deficiency is highly prevalent among children and adolescents worldwide. The high rates of vitamin D deficiency during childhood are of major public health relevance, given the growing evidence that vitamin D deficiency may play a key role in the pathophysiology of many chronic diseases beyond rickets, including autoimmune conditions, cardiovascular diseases, and cancer. Identification, treatment, and prevention of vitamin D deficiency in childhood may therefore have profound health effects throughout the life span. In this review, we discuss the definitions, epidemiology, clinical implications, and treatment of vitamin D deficiency in children and adolescents.
维生素D缺乏在全球儿童和青少年中极为普遍。鉴于越来越多的证据表明，维生素D缺乏可能在除佝偻病之外的许多慢性疾病的病理生理过程中发挥关键作用，包括自身免疫性疾病、心血管疾病和癌症，儿童期维生素D缺乏的高发生率具有重大的公共卫生意义。因此，识别、治疗和预防儿童期维生素D缺乏可能会对整个生命周期产生深远的健康影响。在这篇综述中，我们讨论了儿童和青少年维生素D缺乏的定义、流行病学、临床意义及治疗。
