Kaipiainen-Seppänen O, Savolainen A
Department of Medicine, Kuopio University Hospital, Finland.
Clin Exp Rheumatol. 1996 Jul-Aug;14(4):441-4.
To study trends in the incidence of juvenile rheumatoid arthritis (JRA) and to obtain information on the incidence of other juvenile rheumatic diseases in Finland.
The present study covered those subjects entitled under the nationwide sickness insurance scheme to receive specially reimbursed medication for juvenile rheumatic diseases in 5/21 central hospital districts in Finland (population base about 270,000 children < 16 years of age) in 1980, 1985 and 1990.
A total of 114 incident cases (34 boys, 80 girls) satisfied the criteria for JRA during the three study years: 1980, 1985 and 1990. Seven of the patients had systemic-onset disease. The incidence of JRA remained similar (14/100,000 in the population < 16 years of age). The female: male ratio was 2.4: 1. Only one case of juvenile spondyloarthropathy was found. Seven patients had juvenile systemic lupus erythematosus and four had juvenile dermato/polymyositis. The corresponding annual incidence rates were 0.1, 0.9 and 0.5/100,000, respectively, in this population.
The present study provides population-based figures on the occurrence of various chronic arthritic syndromes in childhood using a unified data base. The incidence of JRA remained quite similar for the three study years. The incidence figures for systemic rheumatic and connective tissue diseases were slightly higher than those reported in previous studies.
研究青少年类风湿性关节炎(JRA)的发病率趋势,并获取芬兰其他青少年风湿性疾病的发病率信息。
本研究涵盖了芬兰5个/21个中央医院辖区内符合全国疾病保险计划规定、有权获得青少年风湿性疾病特殊报销药物的人群(以约270,000名16岁以下儿童为人口基数),研究时间为1980年、1985年和1990年。
在1980年、1985年和1990年这三个研究年度中,共有114例确诊病例(34名男孩,80名女孩)符合JRA标准。其中7例患者患有全身发病型疾病。JRA的发病率保持相似(16岁以下人群中为14/100,000)。女性与男性的比例为2.4:1。仅发现1例青少年脊柱关节病。7例患者患有青少年系统性红斑狼疮,4例患有青少年皮肌炎/多肌炎。该人群中相应的年发病率分别为0.1、0.9和0.5/100,000。
本研究使用统一数据库提供了基于人群的儿童期各种慢性关节炎综合征发病情况的数据。在三个研究年度中,JRA的发病率保持相当相似。系统性风湿性和结缔组织疾病的发病率数字略高于先前研究报告的数字。