Irving E A, Nicoll J, Graham D I, Dewar D
Wellcome Surgical Institute, Glasgow, UK.
Neurosci Lett. 1996 Aug 9;213(3):189-92. doi: 10.1016/0304-3940(96)12856-1.
Tau immunohistochemistry was performed on post-mortem brain tissue from patients who died following head injury or stroke and from neurologically normal controls. Tau-positive oligodendrocytes were detected with three different tau antibodies in head injured or stroke patients, but not in control cases. Tau-positive oligodendrocytes were detected 2 h following head injury indicating that accumulation of tau may be an acute response of these cells to brain injury. The mechanisms underlying accumulation of tau in oligodendrocytes after acute brain injury may be similar to those which occur in chronic neurodegenerative conditions such as progressive supranuclear palsy (PSP) and multi-system atrophy (MSA).
对因头部受伤或中风死亡患者以及神经功能正常的对照者的死后脑组织进行了tau免疫组织化学检测。在头部受伤或中风患者中，用三种不同的tau抗体检测到了tau阳性少突胶质细胞，但在对照病例中未检测到。头部受伤后2小时检测到tau阳性少突胶质细胞，这表明tau的积累可能是这些细胞对脑损伤的急性反应。急性脑损伤后少突胶质细胞中tau积累的潜在机制可能与慢性神经退行性疾病（如进行性核上性麻痹（PSP）和多系统萎缩（MSA））中发生的机制相似。
