Michelucci R, Passarelli D, Riguzzi P, Buzzi A M, Gardella E, Tassinari C A
Department of Neurology, University of Bologna, Bellaria Hospital, Italy.
Acta Neurol Scand. 1996 Jul;94(1):24-30. doi: 10.1111/j.1600-0404.1996.tb00034.x.
Single-pulse transcranial magnetic stimulation (s-TMS) with recording of motor evoked potentials (MEPs) from thenar muscles of both hands was performed on 84 patients with cryptogenic partial epilepsy and 50 healthy controls. We analyzed the cortical latency (CL), central conduction time (CCT), and threshold intensity (TI) required to elicit liminal MEPs at rest. In the patients, CL and CCT were normal, but TI was significantly higher than in the controls. Of the 84 patients, 65 were taking one or more antiepileptic drugs and 19 were untreated. The untreated patients had a significantly lower TI than the treated patients. In the treated patients, the TI increase paralleled the number of drugs taken. Additionally, in 2 subgroups of patients undergoing major modifications of antiepileptic treatment, TI dropped after partial withdrawal of medication and increased following the commencement of therapy. The results suggest that anticonvulsants depress the excitability of human motor pathways in epileptic subjects.
对84例隐源性部分性癫痫患者和50名健康对照者进行了单脉冲经颅磁刺激（s-TMS），并记录双手鱼际肌的运动诱发电位（MEP）。我们分析了静息时引出阈下MEP所需的皮层潜伏期（CL）、中枢传导时间（CCT）和阈强度（TI）。患者的CL和CCT正常，但TI显著高于对照组。84例患者中，65例正在服用一种或多种抗癫痫药物，19例未接受治疗。未治疗的患者TI显著低于接受治疗的患者。在接受治疗的患者中，TI的升高与所服用药物的数量平行。此外，在接受抗癫痫治疗重大调整的2个患者亚组中，部分停药后TI下降，治疗开始后TI升高。结果表明，抗惊厥药会降低癫痫患者人体运动通路的兴奋性。
