Oravcova E, Lacka J, Drgona L, Studena M, Sevcikova L, Spanik S, Svec J, Kukuckova E, Grey E, Silva J, Krcméry V
Dept. of Medicine, University of Trnava, Slovak Republic.
Infection. 1996 Jul-Aug;24(4):319-23. doi: 10.1007/BF01743368.
Fifty cancer patients with funguria of > 10(5) CFU/ml, dysuria and leukocyturia were retrospectively analyzed for etiology, risk factors and outcome. In 72% of cases Candida albicans and in 28% non-albicans Candida spp. (Candida krusei, Candida tropicalis) and non-Candida spp. yeasts (Blastoschizomyces capitatus) were isolated. Torulopsis glabrata was not found among these patients. The most frequent risk factors were: antibiotic therapy with more than one antibiotic agent (96%), concomitant fungal infection in other localizations than the urinary tract (36%), colonization with the same species (48%), catheterization with urinary catheter or nephrostomy (46%), prophylaxis with quinolones (50%) and previous therapy with corticosteroids (72%). Structural or anatomic malformations of the urinary tract (26%), neutropenia (28%), antifungal prophylaxis with azoles (22%), and diabetes mellitus (12%) were less frequently seen. Thirty of 36 patients treated with systemic antifungals were cured and six were not.
对50例真菌尿菌量>10(5) CFU/ml、伴有排尿困难和白细胞尿的癌症患者进行回顾性分析，以明确病因、危险因素及预后。72%的病例分离出白色念珠菌，28%分离出非白色念珠菌属（克柔念珠菌、热带念珠菌）及非念珠菌属酵母（头裂芽生菌）。这些患者中未发现光滑念珠菌。最常见的危险因素为：使用一种以上抗生素进行抗生素治疗（96%）、尿路以外其他部位合并真菌感染（36%）、同种菌定植（48%）、留置导尿管或肾造瘘术（46%）、使用喹诺酮类药物进行预防（50%）以及既往使用皮质类固醇治疗（72%）。尿路结构或解剖畸形（26%）、中性粒细胞减少（28%）、使用唑类药物进行抗真菌预防（22%）以及糖尿病（12%）则较少见。36例接受全身抗真菌治疗的患者中，30例治愈，6例未治愈。
