François P, Vaudaux P, Foster T J, Lew D P
Division of Infectious Diseases, University Hospital, Geneva, Switzerland.
Infect Control Hosp Epidemiol. 1996 Aug;17(8):514-20. doi: 10.1086/647358.
Persistent staphylococcal infections are a major medical problem, especially when they occur on implanted materials or intravascular catheters. This review describes some of the recently discovered molecular mechanisms of Staphylococcus aureus attachment to host proteins coating biomedical implants. These interactions involve specific surface proteins, called bacterial adhesins, that recognize specific domains of host proteins deposited on indwelling devices, such as fibronectin, fibrinogen, or fibrin. Elucidation of molecular mechanisms of S aureus adhesion to the different host proteins may lead to the development of specific inhibitors blocking attachment of S aureus, which may decrease the risk of bacterial colonization of indwelling devices.
持续性葡萄球菌感染是一个重大的医学问题，尤其是当它们发生在植入材料或血管内导管上时。本综述描述了金黄色葡萄球菌附着于生物医学植入物表面宿主蛋白的一些最近发现的分子机制。这些相互作用涉及特定的表面蛋白，称为细菌粘附素，它们识别沉积在留置装置上的宿主蛋白的特定结构域，如纤连蛋白、纤维蛋白原或纤维蛋白。阐明金黄色葡萄球菌与不同宿主蛋白粘附的分子机制可能会导致开发出阻断金黄色葡萄球菌附着的特异性抑制剂，这可能会降低留置装置细菌定植的风险。
