Tune L, Barta P, Wong D, Powers R E, Pearlson G, Tien A Y, Wagner H N
Department of Psychiatry, Emory University, School of Medicine, Wesley Woods Geriatric Teaching and Research Hospital, Atlanta, GA 30329-5102, USA.
Psychiatry Res. 1996 Jul 31;67(2):155-8. doi: 10.1016/0925-4927(96)02728-x.
Chronic schizophrenic (n = 14) and normal subjects (n = 15) were studied with resonance imaging (MRI) and positron emission tomography (PET). Two PET scans were carried out to estimate caudate dopamine D2 receptor densities. MRI was used to measure the volume of the superior temporal gyrus. Average striatal D2 receptor density (Bmax) was significantly higher in the schizophrenic group than in the normal group. Average left superior temporal gyral volume was significantly smaller in the schizophrenic group than in the normal group, and the same tendency was found for the right superior temporal gyrus. Thus, the main finding of this combined analysis of functional and structural neuroimaging techniques was an inverse relationship between reduced superior temporal gyral volume and elevated striatal D2 receptor Bmax values. These preliminary findings require confirmation in larger groups of patients and control subjects.
对14名慢性精神分裂症患者和15名正常受试者进行了磁共振成像（MRI）和正电子发射断层扫描（PET）研究。进行了两次PET扫描以估计尾状核多巴胺D2受体密度。MRI用于测量颞上回的体积。精神分裂症组的平均纹状体D2受体密度（Bmax）显著高于正常组。精神分裂症组的左侧颞上回平均体积显著小于正常组，右侧颞上回也有同样的趋势。因此，这种功能和结构神经成像技术联合分析的主要发现是颞上回体积减小与纹状体D2受体Bmax值升高之间呈负相关。这些初步发现需要在更大规模的患者和对照组中得到证实。
