Sajantila A, Salem A H, Savolainen P, Bauer K, Gierig C, Pääbo S
Zoological Institute, University of Munich, Germany.
Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):12035-9. doi: 10.1073/pnas.93.21.12035.
An analysis of Y-chromosomal haplotypes in several European populations reveals an almost monomorphic pattern in the Finns, whereas Y-chromosomal diversity is significantly higher in other populations. Furthermore, analyses of nucleotide positions in the mitochondrial control region that evolve slowly show a decrease in genetic diversity in Finns. Thus, relatively few men and women have contributed the genetic lineages that today survive in the Finnish population. This is likely to have caused the so-called "Finnish disease heritage"-i.e., the occurrence of several genetic diseases in the Finnish population that are rare elsewhere. A preliminary analysis of the mitochondrial mutations that have accumulated subsequent to the bottleneck suggests that it occurred about 4000 years ago, presumably when populations using agriculture and animal husbandry arrived in Finland.
对几个欧洲人群的Y染色体单倍型分析显示，芬兰人的Y染色体模式几乎是单态的，而其他人群的Y染色体多样性则显著更高。此外，对线粒体控制区中进化缓慢的核苷酸位置的分析表明，芬兰人的遗传多样性有所下降。因此，在当今芬兰人群中存活下来的遗传谱系，其贡献者中男性和女性相对较少。这很可能导致了所谓的“芬兰疾病遗产”，即在芬兰人群中出现了几种在其他地方罕见的遗传疾病。对瓶颈效应之后积累的线粒体突变的初步分析表明，瓶颈效应大约发生在4000年前，大概是在使用农业和畜牧业的人群抵达芬兰的时候。
