艰难梭菌毒素A对体外CD11/CD18表达的影响。
Effect of Clostridium difficile toxin A on CD11/CD18 expression in vitro.
作者信息
Warny M, Chatelain B, Delmée M
机构信息
Unité de Microbiologie, Cliniques Universitaires Saint-Luc Université Catholique de Louvain, Brussels, Belgium.
出版信息
Clin Diagn Lab Immunol. 1996 Sep;3(5):605-7. doi: 10.1128/cdli.3.5.605-607.1996.
Abstract
Clostridium difficile toxin A is chemotactic for neutrophils and induces their emigration into the colonic mucosae of rodents. We found that toxin A did not upregulate neutrophil beta 2 integrins on isolated human neutrophils. These data support the hypothesis that in C. difficile colitis, these adhesion molecules are upregulated by endogenous mediators.
摘要
艰难梭菌毒素A对中性粒细胞具有趋化作用，并诱导其迁移至啮齿动物的结肠黏膜。我们发现毒素A不会上调分离出的人中性粒细胞上的β2整合素。这些数据支持了以下假说：在艰难梭菌结肠炎中，这些黏附分子是由内源性介质上调的。
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