Warny M, Chatelain B, Delmée M
Unité de Microbiologie, Cliniques Universitaires Saint-Luc Université Catholique de Louvain, Brussels, Belgium.
Clin Diagn Lab Immunol. 1996 Sep;3(5):605-7. doi: 10.1128/cdli.3.5.605-607.1996.
Clostridium difficile toxin A is chemotactic for neutrophils and induces their emigration into the colonic mucosae of rodents. We found that toxin A did not upregulate neutrophil beta 2 integrins on isolated human neutrophils. These data support the hypothesis that in C. difficile colitis, these adhesion molecules are upregulated by endogenous mediators.
艰难梭菌毒素A对中性粒细胞具有趋化作用，并诱导其迁移至啮齿动物的结肠黏膜。我们发现毒素A不会上调分离出的人中性粒细胞上的β2整合素。这些数据支持了以下假说：在艰难梭菌结肠炎中，这些黏附分子是由内源性介质上调的。
