Tiihonen J, Kuoppamäki M, Någren K, Bergman J, Eronen E, Syvälahti E, Hietala J
Department of Forensic Psychiatry, University of Kuopio, Niuvanniemi Hospital, Finland.
Psychopharmacology (Berl). 1996 Aug;126(4):277-80. doi: 10.1007/BF02247377.
The modulating effect of serotonergic drugs on the striatal dopamine neurotransmission has remained controversial, and there are no published data on serotonin-dopamine interaction obtained from living human brain. Citalopram is a selective serotonin reuptake inhibitor widely used in the treatment of depression (20-40 mg/day). We measured the effects of acute (20 mg, per os) and chronic (20 mg/day for 14 days) doses of citalopram and placebo intake on [11C]-raclopride binding to striatal D2-receptors in eight healthy volunteers by using positron emission tomography. Although the effect magnitude was not large, the results indicate that chronic citalopram intake slightly decreases the raclopride binding which may reflect increased dopamine release in the striatum. In addition, after 14 days there was a high correlation between the citalopam plasma levels and the decrease in the [11C]-raclopride binding in both the caudate and the putamen, although statistically significant effect in the raclopride binding potential was more pronounced in the putamen. This report suggests functional interaction of brain dopaminergic and serotonergic systems in vivo in man.
血清素能药物对纹状体多巴胺神经传递的调节作用一直存在争议，且尚无从活体人脑获取的关于血清素 - 多巴胺相互作用的公开数据。西酞普兰是一种广泛用于治疗抑郁症（20 - 40毫克/天）的选择性血清素再摄取抑制剂。我们通过正电子发射断层扫描测量了8名健康志愿者口服急性剂量（20毫克）和慢性剂量（20毫克/天，持续14天）的西酞普兰及安慰剂对[11C] - 雷氯必利与纹状体D2受体结合的影响。尽管效应幅度不大，但结果表明长期服用西酞普兰会轻微降低雷氯必利的结合，这可能反映出纹状体中多巴胺释放增加。此外，14天后，西酞普兰血浆水平与尾状核和壳核中[11C] - 雷氯必利结合的降低之间存在高度相关性，尽管雷氯必利结合潜力的统计学显著效应在壳核中更为明显。本报告提示人体体内脑多巴胺能和血清素能系统之间存在功能相互作用。
