从芬兰患者中分离出的耐异烟肼结核分枝杆菌菌株中的katG基因突变。
katG mutations in isoniazid-resistant Mycobacterium tuberculosis isolates recovered from Finnish patients.
作者信息
Marttila H J, Soini H, Huovinen P, Viljanen M K
机构信息
National Public Health Institute, Mycobacterial Reference Laboratory, Turku, Finland.
出版信息
Antimicrob Agents Chemother. 1996 Sep;40(9):2187-9. doi: 10.1128/AAC.40.9.2187.
Abstract
katG and inhA genes from isoniazid-resistant Mycobacterium tuberculosis strains isolated in Finland were examined by PCR or sequencing. By PCR, katG was not detected in 3 of 54 strains. Sequencing of katG from 13 strains showed small point mutations or insertions; a previously described mutation causing a Ser-to-Thr change at position 315 was found in 4 strains, and there were nine new missense mutations of katG. A 209-bp segment of inhA from 17 strains was sequenced, but no mutations were observed. This result indicates that different mutations prevail in different geographical areas.
摘要
通过PCR或测序检测了从芬兰分离出的耐异烟肼结核分枝杆菌菌株的katG和inhA基因。通过PCR，在54株菌株中有3株未检测到katG。对13株菌株的katG进行测序显示存在小的点突变或插入；在4株菌株中发现了先前描述的导致315位丝氨酸到苏氨酸变化的突变，并且有9个新的katG错义突变。对17株菌株的inhA的209bp片段进行了测序，但未观察到突变。这一结果表明不同的突变在不同地理区域占主导。
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