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本文引用的文献

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Comparison of activities of rifapentine and rifampin against Mycobacterium tuberculosis residing in human macrophages.利福喷汀与利福平对驻留在人巨噬细胞内的结核分枝杆菌活性的比较。
Antimicrob Agents Chemother. 1995 Sep;39(9):2073-7. doi: 10.1128/AAC.39.9.2073.
2
Immunomodulation of human peripheral blood mononuclear cell functions by defined lipid fractions of Mycobacterium avium.鸟分枝杆菌特定脂质组分对人外周血单个核细胞功能的免疫调节作用
Infect Immun. 1993 Dec;61(12):5286-93. doi: 10.1128/iai.61.12.5286-5293.1993.
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Phagocytosis of Mycobacterium tuberculosis or particulate stimuli by human monocytic cells induces equivalent monocyte chemotactic protein-1 gene expression.
Cytokine. 1993 Mar;5(2):150-6. doi: 10.1016/1043-4666(93)90054-9.
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Phagocytosis of Mycobacterium tuberculosis modulates human immunodeficiency virus replication in human monocytic cells.结核分枝杆菌的吞噬作用调节人类单核细胞中人类免疫缺陷病毒的复制。
J Gen Virol. 1994 Apr;75 ( Pt 4):849-56. doi: 10.1099/0022-1317-75-4-849.
5
Colorimetric method for determining MICs of antimicrobial agents for Mycobacterium tuberculosis.用于测定结核分枝杆菌抗菌药物最低抑菌浓度的比色法。
J Clin Microbiol. 1995 Sep;33(9):2324-7. doi: 10.1128/jcm.33.9.2324-2327.1995.
6
Expression of interleukin 2 receptors and binding of interleukin 2 by gamma interferon-induced human leukemic and normal monocytic cells.γ干扰素诱导的人白血病及正常单核细胞中白细胞介素2受体的表达及白细胞介素2的结合
J Exp Med. 1985 Sep 1;162(3):1111-6. doi: 10.1084/jem.162.3.1111.
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Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing.基于四氮唑的半自动比色法评估：化学敏感性测试评估
Cancer Res. 1987 Feb 15;47(4):936-42.
8
Macrophage uptake and retention of radiolabeled glycopeptidolipid antigens associated with the superficial L1 layer of Mycobacterium intracellulare serovar 20.巨噬细胞对与胞内分枝杆菌血清型20浅表L1层相关的放射性标记糖肽脂抗原的摄取和保留。
Infect Immun. 1986 Oct;54(1):133-41. doi: 10.1128/iai.54.1.133-141.1986.
9
Establishment of a human cell line (Mono Mac 6) with characteristics of mature monocytes.建立具有成熟单核细胞特征的人细胞系（单核细胞白血病细胞系Mono Mac 6）。
Int J Cancer. 1988 Mar 15;41(3):456-61. doi: 10.1002/ijc.2910410324.
10
Killing by antimycobacterial agents of AIDS-derived strains of Mycobacterium avium complex inside cells of the mouse macrophage cell line J774.小鼠巨噬细胞系J774细胞内抗分枝杆菌药物对艾滋病来源的鸟分枝杆菌复合群菌株的杀伤作用
Am Rev Respir Dis. 1989 Nov;140(5):1198-203. doi: 10.1164/ajrccm/140.5.1198.

在平行抗分枝杆菌药物研究中使用Mono Mac 6人单核细胞系和J774鼠巨噬细胞系。

Use of Mono Mac 6 human monocytic cell line and J774 murine macrophage cell line in parallel antimycobacterial drug studies.

作者信息

Wright E L, Quenelle D C, Suling W J, Barrow W W

机构信息

Mycobacteriology Research Unit, Southern Research Institute, Birmingham, Alabama 35205, USA.

出版信息

Antimicrob Agents Chemother. 1996 Sep;40(9):2206-8. doi: 10.1128/AAC.40.9.2206.

DOI:10.1128/AAC.40.9.2206
PMID:8878609
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC163501/
Abstract

The Mono Mac 6 (MM6) human monocytic cell line was evaluated with the established J774 murine macrophage cell line to ascertain its effectiveness in determining the intracellular activities of antimycobacterial drugs. Cells were infected with Mycobacterium tuberculosis H37Ra and treated with drug concentrations corresponding to the MICs, as well as to threefold higher than and threefold less than the MICs. Changes in CFU were compared after 7 days to determine significant differences between treated and nontreated groups. The results suggest that MM6 will make a useful model for testing the intracellular activities of antituberculosis drugs.

摘要

使用已建立的J774小鼠巨噬细胞系对Mono Mac 6（MM6）人单核细胞系进行评估，以确定其在测定抗分枝杆菌药物细胞内活性方面的有效性。细胞用结核分枝杆菌H37Ra感染，并用相当于最低抑菌浓度（MIC）的药物浓度以及比MIC高三倍和低三倍的药物浓度进行处理。7天后比较菌落形成单位（CFU）的变化，以确定处理组和未处理组之间的显著差异。结果表明，MM6将成为测试抗结核药物细胞内活性的有用模型。